Nudt15 nudix hydrolase 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nudt15provided by RGD
Official Full Name: nudix hydrolase 15provided by RGD
Primary source: RGD:1308292
See related: AllianceGenome:RGD:1308292
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity; and 8-oxo-dGDP phosphatase activity. Predicted to be involved in several processes, including DNA protection; dGTP catabolic process; and regulation of proteasomal protein catabolic process. Predicted to act upstream of or within purine deoxyribonucleoside triphosphate catabolic process and response to reactive oxygen species. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in thiopurine S-methyltransferase deficiency. Orthologous to human NUDT15 (nudix hydrolase 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 63.0), Heart (RPKM 34.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (55117312..55123983, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (48707776..48713847, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (55417774..55456698, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	ISO Inferred from Sequence Orthology more info
enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	ISO Inferred from Sequence Orthology more info
enables 8-oxo-dGDP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside triphosphate diphosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT involved_in DNA protection	ISO Inferred from Sequence Orthology more info
involved_in DNA protection	ISO Inferred from Sequence Orthology more info
involved_in dGTP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dGTP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in nucleoside phosphate catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within purine deoxyribonucleoside triphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in purine nucleotide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nucleotide triphosphate diphosphatase NUDT15

Names: nudix (nucleoside diphosphate linked moiety X)-type motif 15; probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15; probable 8-oxo-dGTP diphosphatase NUDT15

NP_001099519.1

EC 3.6.1.55

XP_063130221.1

EC 3.6.1.55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106049.2 → NP_001099519.1 nucleotide triphosphate diphosphatase NUDT15

See identical proteins and their annotated locations for NP_001099519.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A6HTQ8, D3ZKQ0

Conserved Domains (1) summary

cd04678
Location:27 → 142

Nudix_Hydrolase_19; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...