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    Sgcz sarcoglycan zeta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364605, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sgczprovided by RGD
    Official Full Name
    sarcoglycan zetaprovided by RGD
    Primary source
    RGD:1307788
    See related
    EnsemblRapid:ENSRNOG00000057716 AllianceGenome:RGD:1307788
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in plasma membrane. Predicted to be part of sarcoglycan complex. Orthologous to human SGCZ (sarcoglycan zeta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 17.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sgcz in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (60363718..61444256)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (53660283..54740811)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (57136433..58206350)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 27 Neighboring gene uncharacterized LOC108353112 Neighboring gene uncharacterized LOC120097547 Neighboring gene uncharacterized LOC120097546 Neighboring gene uncharacterized LOC134482510 Neighboring gene uncharacterized LOC120097544 Neighboring gene uncharacterized LOC134482388 Neighboring gene uncharacterized LOC134482389 Neighboring gene microRNA 383 Neighboring gene DEAD-box helicase 18, pseudogene 1 Neighboring gene eukaryotic translation initiation factor 2 subunit alpha, pseudogene 3 Neighboring gene uncharacterized LOC134482509 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134482550 Neighboring gene uncharacterized LOC134482551

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy. Wheeler MT, et al. Hum Mol Genet, 2002 Sep 1. PMID 12189167
    2. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Xiao HS, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060780, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cardiac muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of sarcoglycan complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sarcoglycan complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zeta-sarcoglycan

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108875.2 → NP_001102345.2  zeta-sarcoglycan

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A0G2K1J1
      Related
      ENSRNOP00000109565.1, ENSRNOT00000141405.1
      Conserved Domains (1) summary
      pfam04790
      Location:43 → 296
      Sarcoglycan_1; Sarcoglycan complex subunit protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      60363718..61444256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094728.2 → XP_038950656.1  zeta-sarcoglycan isoform X2

      Conserved Domains (1) summary
      pfam04790
      Location:5 → 222
      Sarcoglycan_1; Sarcoglycan complex subunit protein

    2. XM_039094727.2 → XP_038950655.1  zeta-sarcoglycan isoform X1

      UniProtKB/TrEMBL
      A6IVJ3
      Conserved Domains (1) summary
      pfam04790
      Location:25 → 283
      Sarcoglycan_1; Sarcoglycan complex subunit protein

    3. XM_039094729.2 → XP_038950657.1  zeta-sarcoglycan isoform X2

      Conserved Domains (1) summary
      pfam04790
      Location:5 → 222
      Sarcoglycan_1; Sarcoglycan complex subunit protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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