Htra4 HtrA serine peptidase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Htra4provided by RGD
Official Full Name: HtrA serine peptidase 4provided by RGD
Primary source: RGD:1306242
See related: EnsemblRapid:ENSRNOG00000061160 AllianceGenome:RGD:1306242
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306242
Summary: Predicted to enable identical protein binding activity and serine-type endopeptidase activity. Predicted to be involved in positive regulation of apoptotic process; programmed cell death; and proteolysis. Predicted to be located in extracellular region. Orthologous to human HTRA4 (HtrA serine peptidase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 95.2), Lung (RPKM 87.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.4

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (73704255..73717722)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (67001605..67015074)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (71784819..71802765)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI598828 (e-PCR)
- UniSTS:260724

RH128869 (e-PCR)
- UniSTS:212177

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in programmed cell death	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine protease HTR4

Names: high-temperature requirement factor A4; probable serine protease HTRA4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107321.3 → NP_001100791.1 serine protease HTR4 precursor

See identical proteins and their annotated locations for NP_001100791.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

D3ZKF5

UniProtKB/TrEMBL

A0A0G2JZB1

Related

ENSRNOP00000070978.2, ENSRNOT00000080084.3

Conserved Domains (5) summary

COG0265
Location:150 → 484

DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]

cd00987
Location:391 → 482

PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...

pfam00219
Location:44 → 98

IGFBP; Insulin-like growth factor binding protein

pfam07648
Location:121 → 163

Kazal_2; Kazal-type serine protease inhibitor domain

pfam13365
Location:213 → 351

Trypsin_2; Trypsin-like peptidase domain