Slc7a2 solute carrier family 7 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc7a2provided by RGD
Official Full Name: solute carrier family 7 member 2provided by RGD
Primary source: RGD:68387
See related: EnsemblRapid:ENSRNOG00000011016 AllianceGenome:RGD:68387
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cat2; Cat2a; Cat2b
Summary: Enables L-arginine transmembrane transporter activity. Involved in L-arginine transmembrane transport. Predicted to be located in cell junction and membrane. Predicted to be active in plasma membrane. Orthologous to human SLC7A2 (solute carrier family 7 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 489.0), Lung (RPKM 56.9) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (58115991..58174256, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (51417478..51470784, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (54459409..54513349, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CAT1, CAT2, DDAH2, and arginase-1 expression in renal resistance vessels is regulated through the AT(1) receptor.
Title: AT(1) receptor activation regulates the mRNA expression of CAT1, CAT2, arginase-1, and DDAH2 in preglomerular vessels from angiotensin II hypertensive rats.
HO-1 overexpression significantly attenuates endotoxin-induced increases in nitric oxide and l-arginine transport, as well as the expression of iNOS and CAT-2 isozymes in septic rats.
Title: HO-1 overexpression attenuates endotoxin effects on CAT-2 isozymes expression.
In mesangial cells, expression of both CAT-1 and CAT-2 mRNA was augmented after incubation with LPS. In vivo administration of LPS produced a significant increase in glomerular cationic amino acid transporter-2 (CAT-2) mRNA expression but not CAT-1 mRNA
Title: Differential regulation of glomerular arginine transporters (CAT-1 and CAT-2) in lipopolysaccharide-treated rats.
Ischemic ARF is associated with augmented tubular CAT-2 mRNA expression, which leads to enhanced l-Arg transport and increased NO production.
Title: L-Arginine transport is augmented through up-regulation of tubular CAT-2 mRNA in ischemic acute renal failure in rats.
Dexamethasone induces cyclohydrolase 1 and CAT-2 exression in lung.
Title: Dexamethasone suppresses iNOS yet induces GTPCH and CAT-2 mRNA expression in rat lungs.
In macrophages LPS up-regulates CAT-2B mRNA expression simultaneously with inducible NO Synthase(iNOS)resulting in increased L-arginine transport. Up-regulation of CAT-2B mRNA expression involves NF-kappaB activiation.
Title: Nuclear factor-kappaB mediates simultaneous induction of inducible nitric-oxide synthase and Up-regulation of the cationic amino acid transporter CAT-2B in rat alveolar macrophages.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-arginine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-arginine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-arginine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-arginine transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables L-lysine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-ornithine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-alpha-amino acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in L-arginine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-arginine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-arginine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within L-arginine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-arginine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-lysine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-ornithine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within macrophage activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nitric oxide production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of macrophage activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cationic amino acid transporter 2

Names: CAT-2; cationic amino acid transporter-2A; low affinity cationic amino acid transporter 2; solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134686.2 → NP_001128158.1 cationic amino acid transporter 2 isoform b

See identical proteins and their annotated locations for NP_001128158.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (2) uses an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform b) is longer but has the same N- and C-termini compared to isoform a.

Source sequence(s)

AF245002

UniProtKB/TrEMBL

Q925V9

Related

ENSRNOP00000014809.3, ENSRNOT00000014809.7

Conserved Domains (1) summary

TIGR00906
Location:5 → 608

2A0303; cationic amino acid transport permease
NM_022619.3 → NP_072141.2 cationic amino acid transporter 2 isoform a

See identical proteins and their annotated locations for NP_072141.2

Status: PROVISIONAL

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform a).

Source sequence(s)

AF245001

UniProtKB/Swiss-Prot

B5D5N9, B5D5P0

UniProtKB/TrEMBL

Q925V9

Related

ENSRNOP00000015127.4, ENSRNOT00000015127.7

Conserved Domains (2) summary

TIGR00906
Location:5 → 607

2A0303; cationic amino acid transport permease

pfam13906
Location:555 → 605

AA_permease_C; C-terminus of AA_permease

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

58115991..58174256 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094810.2 → XP_038950738.1 cationic amino acid transporter 2 isoform X1

UniProtKB/TrEMBL

Q925V9

Conserved Domains (1) summary

TIGR00906
Location:5 → 608

2A0303; cationic amino acid transport permease