H1f1 H1.1 linker histone, cluster member [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: H1f1provided by RGD
Official Full Name: H1.1 linker histone, cluster memberprovided by RGD
Primary source: RGD:1305706
See related: AllianceGenome:RGD:1305706
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: H1-1; Hist1h1a
Summary: Predicted to enable double-stranded DNA binding activity; heparin binding activity; and nucleosomal DNA binding activity. Predicted to be involved in several processes, including chromosome condensation; negative regulation of DNA recombination; and positive regulation of receptor-mediated endocytosis. Predicted to be located in several cellular components, including cell surface; euchromatin; and nucleoplasm. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human H1-1 (H1.1 linker histone, cluster member). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 17p11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (41762278..41794876, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (41366268..41367011, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (43614101..43614844, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Binding of histone H1 to DNA is differentially modulated by redox state of HMGB1.
Title: Binding of histone H1 to DNA is differentially modulated by redox state of HMGB1.
Histone H1 is both an anchoring protein and a substrate for activated PKCepsilon
Title: Identification of the linker histone H1 as a protein kinase Cepsilon-binding protein in vascular smooth muscle.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables nucleosomal DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in euchromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone H1.1

Names: histone 1, H1a; histone H1a; histone cluster 1 H1 family member a; histone cluster 1, H1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106113.1 → NP_001099583.1 histone H1.1

See identical proteins and their annotated locations for NP_001099583.1

Status: PROVISIONAL

Source sequence(s)

CH474064

UniProtKB/Swiss-Prot

D4A3K5

Conserved Domains (1) summary

cd00073
Location:36 → 121

H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...