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    Phactr1 phosphatase and actin regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306844, updated on 9-Dec-2024

    Summary

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    Symbol
    Phactr1provided by RGD
    Full Name
    phosphatase and actin regulator 1provided by RGD
    Primary source
    RGD:1303187
    See related
    EnsemblRapid:ENSRNOG00000014264 AllianceGenome:RGD:1303187
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein phosphatase 1 binding activity. Involved in several processes, including cellular response to mechanical stimulus; regulation of modification of postsynaptic structure; and regulation of phosphorylation. Located in cytoplasm and nucleus. Is active in glutamatergic synapse and postsynapse. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in artery disease (multiple) and brain disease (multiple). Orthologous to human PHACTR1 (phosphatase and actin regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 252.9), Lung (RPKM 90.8) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Phactr1 in Genome Data Viewer
    Location:
    17p14-p12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (21769006..22246227, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (21560364..22040166, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (23245423..23761207)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547830 Neighboring gene eukaryotic translation initiation factor 1-like Neighboring gene uncharacterized LOC134482703 Neighboring gene TBC1 domain family, member 7 Neighboring gene uncharacterized LOC134482770 Neighboring gene uncharacterized LOC120097835 Neighboring gene Jupiter microtubule associated 1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PHACTR1 is associated with disease progression in Chinese Moyamoya disease. Yang Y, et al. PeerJ, 2020. PMID 32411507, Free PMC Article
    2. Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants. Winsvold BS, et al. PLoS One, 2017. PMID 28957430, Free PMC Article
    3. PHACTR1 genotype predicts coronary artery disease in patients with familial hypercholesterolemia. Paquette M, et al. J Clin Lipidol, 2018 Jul-Aug. PMID 29784573
    4. Investigating Coronary Artery Disease methylome through targeted bisulfite sequencing. Ghose S, et al. Gene, 2019 Dec 30. PMID 31499127
    5. Differential expression of PHACTR1 in atheromatous versus normal carotid artery tissue. Green IE, et al. J Clin Neurosci, 2020 Apr. PMID 31980275

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phactr1 seems to regulate the skeletal to cardiac alpha-actin isoform ratio.
      Title: The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112561

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables actin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in actomyosin structure organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actomyosin structure organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cerebral cortex development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendrite arborization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dendrite arborization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dendrite arborization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of modification of postsynaptic structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of modification of postsynaptic structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatase and actin regulator 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214457.2 → NP_999622.2  phosphatase and actin regulator 1

      See identical proteins and their annotated locations for NP_999622.2

      Status: PROVISIONAL

      Source sequence(s)
      BC098634
      UniProtKB/TrEMBL
      A0A8I6ATP4
      Conserved Domains (2) summary
      smart00707
      Location:461 → 485
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:140 → 161
      RPEL; RPEL repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      21769006..22246227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095677.2 → XP_038951605.1  phosphatase and actin regulator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5XW51, A6J754
      Conserved Domains (2) summary
      smart00707
      Location:530 → 554
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:140 → 161
      RPEL; RPEL repeat

    2. XM_063276382.1 → XP_063132452.1  phosphatase and actin regulator 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ATP4

    3. XM_063276381.1 → XP_063132451.1  phosphatase and actin regulator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5XW51, A6J754

    4. XM_039095676.2 → XP_038951604.1  phosphatase and actin regulator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5XW51, A6J754
      Conserved Domains (2) summary
      smart00707
      Location:530 → 554
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:140 → 161
      RPEL; RPEL repeat

    5. XM_039095681.2 → XP_038951609.1  phosphatase and actin regulator 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ATP4
      Related
      ENSRNOP00000097958.1, ENSRNOT00000110352.2
      Conserved Domains (2) summary
      smart00707
      Location:461 → 485
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:140 → 161
      RPEL; RPEL repeat

    6. XM_039095678.2 → XP_038951606.1  phosphatase and actin regulator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5XW51, A6J754
      Related
      ENSRNOP00000077447.1, ENSRNOT00000106668.2
      Conserved Domains (2) summary
      smart00707
      Location:530 → 554
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:140 → 161
      RPEL; RPEL repeat

    7. XM_063276384.1 → XP_063132454.1  phosphatase and actin regulator 1 isoform X8

    8. XM_039095683.2 → XP_038951611.1  phosphatase and actin regulator 1 isoform X6

      Conserved Domains (2) summary
      smart00707
      Location:438 → 462
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:48 → 69
      RPEL; RPEL repeat

    9. XM_063276383.1 → XP_063132453.1  phosphatase and actin regulator 1 isoform X5

    10. XM_039095679.2 → XP_038951607.1  phosphatase and actin regulator 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZKJ8
      Related
      ENSRNOP00000078261.1, ENSRNOT00000107421.2
      Conserved Domains (2) summary
      smart00707
      Location:524 → 548
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:134 → 155
      RPEL; RPEL repeat

    11. XM_039095680.2 → XP_038951608.1  phosphatase and actin regulator 1 isoform X3

      Related
      ENSRNOP00000043053.6, ENSRNOT00000046523.6
      Conserved Domains (2) summary
      smart00707
      Location:482 → 506
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:92 → 113
      RPEL; RPEL repeat

    12. XM_039095685.2 → XP_038951613.1  phosphatase and actin regulator 1 isoform X7

      UniProtKB/TrEMBL
      F1LNB2
      Conserved Domains (2) summary
      smart00707
      Location:413 → 437
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:92 → 113
      RPEL; RPEL repeat

    13. XM_039095684.2 → XP_038951612.1  phosphatase and actin regulator 1 isoform X6

      Conserved Domains (2) summary
      smart00707
      Location:438 → 462
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:48 → 69
      RPEL; RPEL repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62024.1 GenPept UniProtKB/Swiss-Prot:P62024

    Gene LinkOut

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