Hist1h2ail1 histone cluster 1 H2a family member I like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hist1h2ail1provided by RGD
Official Full Name: histone cluster 1 H2a family member I like 1provided by RGD
Primary source: RGD:1311554
See related: EnsemblRapid:ENSRNOG00000087873 AllianceGenome:RGD:1311554
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: H3 histone; Hist1h2ail
Summary: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be involved in epigenetic regulation of gene expression and nucleosome assembly. Predicted to act upstream of with a positive effect on gene expression. Predicted to be located in nucleoplasm. Predicted to be part of nucleosome. Orthologous to several human genes including H3C4 (H3 clustered histone 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 17p11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (41996216..41997128, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (41568181..41569093, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (43814773..43815183, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that maternal protein restriction during gestation results in reduced acetylation of histone H3 in mammary gland of offspring; histone modifications occur at promoter for cyclin-dependent kinase inhibitor 1A in offspring mammary gland.
Title: A gestational low-protein diet represses p21(WAF1/Cip1) expression in the mammary gland of offspring rats through promoter histone modifications.
Acute stress increased the levels of H3K9 tri-methylation in the dentate gyrus and CA1, while it reduced levels of H3K9 mono-methylation and H3K27 tri-methylation in the same regions, and had no effect on levels of H3K4 tri-methylation.
Title: Regulation of hippocampal H3 histone methylation by acute and chronic stress.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epigenetic regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect gene expression	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone H3.1

Names: histone 1, H2ai; histone cluster 1, H2ai-like; histone cluster 1, H2ai-like1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.