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    Spink6 serine peptidase inhibitor, Kazal type 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 408235, updated on 9-Dec-2024

    Summary

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    Symbol
    Spink6provided by RGD
    Full Name
    serine peptidase inhibitor, Kazal type 6provided by RGD
    Primary source
    RGD:1303338
    See related
    EnsemblRapid:ENSRNOG00000013073 AllianceGenome:RGD:1303338
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spink5l1
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to act upstream of or within negative regulation of serine-type endopeptidase activity. Predicted to be located in extracellular region. Orthologous to human SPINK6 (serine peptidase inhibitor Kazal type 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spink6 in Genome Data Viewer
    Location:
    18q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (36648725..36660902)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (36397833..36410010)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (43033066..43044975, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene serine peptidase inhibitor, Kazal type 5 Neighboring gene serine peptidase inhibitor, Kazal type 14 Neighboring gene serine peptidase inhibitor, Kazal type 9 Neighboring gene MARCO like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Spink6 in mouse skin: the conserved inhibitor of kallikrein-related peptidases is reduced by barrier injury. Fischer J, et al. J Invest Dermatol, 2014 May. PMID 24352040
    2. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article
    3. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine protease inhibitor Kazal-type 6
    Names
    Kazal type serine protease inhibitor 1
    serine protease inhibitor Kazal-type 6-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395746.1 → NP_001382675.1  serine protease inhibitor Kazal-type 6 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6KUC6, G3V7Q1
      Related
      ENSRNOP00000017489.1, ENSRNOT00000017489.4
      Conserved Domains (1) summary
      pfam00050
      Location:61 → 105
      Kazal_1; Kazal-type serine protease inhibitor domain

    2. NM_001395747.1 → NP_001382676.1  serine protease inhibitor Kazal-type 6 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6GEN6
      Related
      ENSRNOP00000086998.1, ENSRNOT00000116763.2
      Conserved Domains (1) summary
      pfam00050
      Location:36 → 80
      Kazal_1; Kazal-type serine protease inhibitor domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      36648725..36660902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277500.1 → XP_063133570.1  serine protease inhibitor Kazal-type 6 isoform X1

      UniProtKB/Swiss-Prot
      Q6IE47

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001008874.1: Suppressed sequence

      Description
      NM_001008874.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IE47.1 GenPept UniProtKB/Swiss-Prot:Q6IE47

    Gene LinkOut

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