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    Esco1 establishment of sister chromatid cohesion N-acetyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680014, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Esco1provided by RGD
    Official Full Name
    establishment of sister chromatid cohesion N-acetyltransferase 1provided by RGD
    Primary source
    RGD:1596873
    See related
    EnsemblRapid:ENSRNOG00000014031 AllianceGenome:RGD:1596873
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity; peptide-lysine-N-acetyltransferase activity; and zinc ion binding activity. Predicted to be involved in mitotic sister chromatid cohesion; protein acetylation; and regulation of DNA replication. Predicted to be located in chromatin. Predicted to be active in nucleus. Orthologous to human ESCO1 (establishment of sister chromatid cohesion N-acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 169.0), Spleen (RPKM 149.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Esco1 in Genome Data Viewer
    Location:
    18p13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (1904748..1959609, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (1630560..1686803, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (1789796..1857271, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene GREB1 like retinoic acid receptor coactivator Neighboring gene heat shock protein family D (Hsp60) member 1 like 1 Neighboring gene SAP domain containing ribonucleoprotein, pseudogene 2 Neighboring gene protein RCC2-like Neighboring gene ATP synthase membrane subunit G like 4 Neighboring gene uncharacterized LOC134482900 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nuclear ribonucleoprotein D1 polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1. Rivera-Colón Y, et al. J Biol Chem, 2016 Dec 16. PMID 27803161, Free PMC Article
    2. Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis. Kouznetsova E, et al. Structure, 2016 May 3. PMID 27112597
    3. Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion. Hou F, et al. Mol Biol Cell, 2005 Aug. PMID 15958495, Free PMC Article
    4. Cohesin acetylation speeds the replication fork. Terret ME, et al. Nature, 2009 Nov 12. PMID 19907496, Free PMC Article
    5. Sororin mediates sister chromatid cohesion by antagonizing Wapl. Nishiyama T, et al. Cell, 2010 Nov 24. PMID 21111234

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyltransferase ESCO1
    Names
    establishment of cohesion 1 homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126299.2 → NP_001119771.2  N-acetyltransferase ESCO1

      See identical proteins and their annotated locations for NP_001119771.2

      Status: VALIDATED

      Source sequence(s)
      BC166441
      UniProtKB/TrEMBL
      B2GUX2
      Related
      ENSRNOP00000032270.4, ENSRNOT00000033312.7
      Conserved Domains (2) summary
      pfam13878
      Location:604 → 643
      zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
      pfam13880
      Location:763 → 831
      Acetyltransf_13; ESCO1/2 acetyl-transferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      1904748..1959609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277580.1 → XP_063133650.1  N-acetyltransferase ESCO1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y5R8, A0A8I6GBM2, A6KNE2
      Related
      ENSRNOP00000079439.2, ENSRNOT00000100138.2

    2. XM_063277581.1 → XP_063133651.1  N-acetyltransferase ESCO1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y5R8, A0A8I6GBM2, A6KNE2

    3. XM_063277582.1 → XP_063133652.1  N-acetyltransferase ESCO1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y5R8, A0A8I6GBM2, A6KNE2

    4. XM_039097119.2 → XP_038953047.1  N-acetyltransferase ESCO1 isoform X2

      Related
      ENSRNOP00000076410.2, ENSRNOT00000118344.2
      Conserved Domains (1) summary
      pfam13880
      Location:719 → 787
      Acetyltransf_13; ESCO1/2 acetyl-transferase

    5. XM_063277577.1 → XP_063133647.1  N-acetyltransferase ESCO1 isoform X1

      UniProtKB/TrEMBL
      B2GUX2

    6. XM_039097120.2 → XP_038953048.1  N-acetyltransferase ESCO1 isoform X3

      Conserved Domains (1) summary
      pfam13878
      Location:604 → 643
      zf-C2H2_3; zinc-finger of acetyl-transferase ESCO

    7. XM_063277578.1 → XP_063133648.1  N-acetyltransferase ESCO1 isoform X4

    8. XM_063277579.1 → XP_063133649.1  N-acetyltransferase ESCO1 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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