Siah1 siah E3 ubiquitin protein ligase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Siah1provided by RGD
Official Full Name: siah E3 ubiquitin protein ligase 1provided by RGD
Primary source: RGD:620449
See related: EnsemblRapid:ENSRNOG00000015143 AllianceGenome:RGD:620449
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SIAH; Siah1a
Summary: Enables ubiquitin-protein transferase activity. Involved in neuron apoptotic process; protein destabilization; and ubiquitin-dependent protein catabolic process. Located in cytosol; early endosome; and nucleus. Orthologous to human SIAH1 (siah E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 51.2), Adrenal (RPKM 48.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (36552165..36575773)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (20378908..20402512)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (21372163..21395773)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that siah1 is involved in homocysteineinduced cell damage by promoting the nuclear translocation of glyceraldehyde 3phosphate dehydrogenase .
Title: E3 ubiquitin ligase siah‑1 nuclear accumulation is critical for homocysteine‑induced impairment of C6 astroglioma cells.
Study reveals GAPDH/Siah1 as a novel signaling pathway in apoptosis and function recovery after traumatic spinal cord injury. This signaling pathway in the spinal cord can be blocked by sivelestat sodium.
Title: GAPDH/Siah1 cascade is involved in traumatic spinal cord injury and could be attenuated by sivelestat sodium.
The results of this study indicated that CacyBP/SIP is a novel regulator of CRE- and NFAT-driven transcription.
Title: Calcyclin-binding protein/Siah-1-interacting protein as a regulator of transcriptional responses in brain cells.
Data suggest SIAH1 involvement in the injury response of the adult spinal cord of the rats.
Title: An upregulation of SIAH1 after spinal cord injury in adult rats.
siah-1 Protein is necessary for high glucose-induced glyceraldehyde-3-phosphate dehydrogenase nuclear accumulation and cell death in Muller
Title: siah-1 Protein is necessary for high glucose-induced glyceraldehyde-3-phosphate dehydrogenase nuclear accumulation and cell death in Muller cells.
synphilin-1A has a novel role as a regulator of SIAH activity, modulating alpha-synuclein, and formation of Lewy body-like inclusions
Title: Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation.
These results suggest that Siah-1 might play a role as a regulator of FIH abundance under normoxic conditions.
Title: Abundance of aspargynyl-hydroxylase FIH is regulated by Siah-1 under normoxic conditions.
Binds group I metabotropic glutamate receptors and calmodulin; calmodulin binding may play a role in the regulation of group I mGluR function
Title: A role for Seven in Absentia Homolog (Siah1a) in metabotropic glutamate receptor signaling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136650 (e-PCR)
- UniSTS:218741

MARC_14423-14424:1010076472:1 (e-PCR)
- UniSTS:267663

MARC_14423-14424:1027951438:1 (e-PCR)
- UniSTS:267663

D19Rat111 (e-PCR)
- UniSTS:239311

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within male meiosis I	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of beta-catenin destruction complex	IEA Inferred from Electronic Annotation more info
part_of beta-catenin destruction complex	ISO Inferred from Sequence Orthology more info
part_of beta-catenin destruction complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase SIAH1

Names: RING-type E3 ubiquitin transferase SIAH1; seven in absentia 1A; seven in absentia homolog 1; siah-1; siah-1a

NP_543181.2

EC 2.3.2.27

XP_008770567.1

EC 2.3.2.27

XP_038953365.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080905.2 → NP_543181.2 E3 ubiquitin-protein ligase SIAH1

See identical proteins and their annotated locations for NP_543181.2

Status: VALIDATED

Source sequence(s)

AF389476, BQ780107, DV213782

UniProtKB/Swiss-Prot

Q06984, Q920M9

UniProtKB/TrEMBL

A0A8I6APD1, A9UK92

Related

ENSRNOP00000020329.5, ENSRNOT00000020329.8

Conserved Domains (2) summary

cd16751
Location:39 → 78

RING-HC_SIAH1; RING finger, HC subclass, found in seven in absentia homolog 1 (SIAH1) and similar proteins

pfam03145
Location:82 → 278

Sina; Seven in absentia protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

36552165..36575773

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772345.4 → XP_008770567.1 E3 ubiquitin-protein ligase SIAH1 isoform X1

See identical proteins and their annotated locations for XP_008770567.1

UniProtKB/Swiss-Prot

Q06984, Q920M9

UniProtKB/TrEMBL

A0A8I6APD1, A9UK92

Related

ENSRNOP00000103855.1, ENSRNOT00000156871.1

Conserved Domains (2) summary

cd16751
Location:39 → 78

RING-HC_SIAH1; RING finger, HC subclass, found in seven in absentia homolog 1 (SIAH1) and similar proteins

pfam03145
Location:82 → 278

Sina; Seven in absentia protein family
XM_039097437.2 → XP_038953365.1 E3 ubiquitin-protein ligase SIAH1 isoform X1

UniProtKB/Swiss-Prot

Q06984, Q920M9

UniProtKB/TrEMBL

A0A8I6APD1, A9UK92

Related

ENSRNOP00000104306.1, ENSRNOT00000155668.1

Conserved Domains (2) summary

cd16751
Location:39 → 78

RING-HC_SIAH1; RING finger, HC subclass, found in seven in absentia homolog 1 (SIAH1) and similar proteins

pfam03145
Location:82 → 278

Sina; Seven in absentia protein family