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    Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phlpp2provided by RGD
    Official Full Name
    PH domain and leucine rich repeat protein phosphatase 2provided by RGD
    Primary source
    RGD:1562857
    See related
    EnsemblRapid:ENSRNOG00000016108 AllianceGenome:RGD:1562857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Phlppl; RGD1562857
    Summary
    Enables protein serine/threonine phosphatase activity. Involved in hippocampus development and protein dephosphorylation. Located in photoreceptor inner segment and photoreceptor outer segment membrane. Orthologous to human PHLPP2 (PH domain and leucine rich repeat protein phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 114.1), Kidney (RPKM 94.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Phlpp2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (54744581..54811258)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (37835125..37901804)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (41731845..41798451, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 1 subunit gamma 1 Neighboring gene uncharacterized LOC120098498 Neighboring gene small nucleolar RNA, C/D box 71 Neighboring gene MARVEL domain containing 3 Neighboring gene tyrosine aminotransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Activation of PH-domain leucine-rich protein phosphatase 2 (PHLPP2) by agonist stimulation in cardiac myocytes expressing adenylyl cyclase type 6. Gao MH, et al. Biochem Biophys Res Commun, 2009 Jun 26. PMID 19450723, Free PMC Article
    2. PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) regulates G-protein-coupled receptor kinase 5 (GRK5)-induced cardiac hypertrophy in vitro. Yeh ST, et al. J Biol Chem, 2018 May 25. PMID 29628444, Free PMC Article
    3. Morin mitigates acetaminophen-induced liver injury by potentiating Nrf2 regulated survival mechanism through molecular intervention in PHLPP2-Akt-Gsk3β axis. Rizvi F, et al. Apoptosis, 2015 Oct. PMID 26286854
    4. Signaling specificity in the Akt pathway in biology and disease. Toker A, et al. Adv Biol Regul, 2014 May. PMID 24794538, Free PMC Article
    5. PHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus. Jackson TC, et al. J Neurochem, 2010 Nov. PMID 20819118, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Phlpp2 expression is associated with cardiac hypertrophy.
      Title: PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) regulates G-protein-coupled receptor kinase 5 (GRK5)-induced cardiac hypertrophy in vitro.
    2. Cellular PHLPP2 levels may aggravate oxidative toxicity by suppressing Nrf2/ARE transcriptional regulation via Akt(Se473)/GSK3beta/Fyn kinase axis.
      Title: Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatocellular toxicity.
    3. increased Akt activity was associated with inhibition of PHLPP2 activity by adenylyl cyclase type 6.
      Title: Activation of PH-domain leucine-rich protein phosphatase 2 (PHLPP2) by agonist stimulation in cardiac myocytes expressing adenylyl cyclase type 6.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hippocampus development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in photoreceptor outer segment membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PH domain leucine-rich repeat-containing protein phosphatase 2
    NP_001102601.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109131.2 → NP_001102601.2  PH domain leucine-rich repeat-containing protein phosphatase 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZ38, D4A254
      Related
      ENSRNOP00000021745.7, ENSRNOT00000021744.8
      Conserved Domains (5) summary
      PLN00113
      Location:284 → 762
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      cd00143
      Location:820 → 1069
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      cd13322
      Location:185 → 279
      PH_PHLPP-like; PH domain leucine-rich repeat protein phosphatase family Pleckstrin homology-like domain
      sd00033
      Location:360 → 382
      LRR_RI; leucine-rich repeat [structural motif]
      cd17241
      Location:66 → 178
      RA_PHLPP2; Ras-associating (RA) domain found in PH domain leucine-rich repeat-containing protein phosphatase 2 (PHLPP2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      54744581..54811258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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