Cdh5 cadherin 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdh5provided by RGD
Official Full Name: cadherin 5provided by RGD
Primary source: RGD:1307370
See related: EnsemblRapid:ENSRNOG00000013324 AllianceGenome:RGD:1307370
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including beta-catenin binding activity; enzyme binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell junction organization; and regulation of protein-containing complex assembly. Predicted to act upstream of or within blood vessel maturation; cell-cell adhesion; and negative regulation of cell population proliferation. Predicted to be located in cell-cell junction; external side of plasma membrane; and nucleus. Predicted to be part of catenin complex. Predicted to be active in adherens junction and bicellular tight junction. Biomarker of pulmonary hypertension. Orthologous to human CDH5 (cadherin 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 824.9), Heart (RPKM 362.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p14

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (821875..860931, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (815415..854478, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (1025122..1074333, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased expression of VE-cadherin was detected in intracranial aneurysm endothelium.
Title: Role of Vascular Endothelial-Cadherin and p120-Catenin in the Formation of Experimental Intracranial Aneurysm in Animals.
these results suggested that Ang II inhibited the protein expression of ZO1 in vascular endothelial cells by downregulating VEcadherin, thus destroying the tight junctions between endothelial cells, which may also be the mechanism by which Ang II is involved in the development of cardiovascular diseases.
Title: Angiotensin II inhibits the protein expression of ZO‑1 in vascular endothelial cells by downregulating VE‑cadherin.
Rab Gtpases regulate VE-cadherin levels at the cell surface to modulate the pulmonary endothelium.
Title: Select Rab GTPases Regulate the Pulmonary Endothelium via Endosomal Trafficking of Vascular Endothelial-Cadherin.
Transcriptional repression of VE-cadherin by nitrosative stress is involved in endothelial-mesenchymal transdifferentiation in experimental pulmonary hypertension.
Title: Vascular endothelial-cadherin downregulation as a feature of endothelial transdifferentiation in monocrotaline-induced pulmonary hypertension.
Changes in the SRC kinase mediated phosphorylation status of caveolin1 and VEcadherin may be involved in pulmonary microvascular permeability following cardiopulmonary bypass.
Title: Cardiopulmonary bypass increases pulmonary microvascular permeability through the Src kinase pathway: Involvement of caveolin-1 and vascular endothelial cadherin.
Nitric oxide increases arterial endotheial permeability through mediating VE-Cadherin expression during arteriogenesis.
Title: Nitric Oxide Increases Arterial Endotheial Permeability through Mediating VE-Cadherin Expression during Arteriogenesis.
Our studies indicate that diabetic conditions prime endothelial cells into a phenotype with increased susceptibility to inflammation without altering receptor expression and that the increased Rho activation.
Title: Enhanced permeability responses to inflammation in streptozotocin-induced diabetic rat venules: Rho-mediated alterations of actin cytoskeleton and VE-cadherin.
Reverse-flow perfusions of mesenteric venules showed numerous small gaps in VE-cadherin expression on the endothelium. Similar gaps were not seen in vessels perfused in the forward direction.
Title: Microvascular permeability to water is independent of shear stress, but dependent on flow direction.
Data show that the expression of VE-cadherin was markedly decreased on hypoxia/reoxygenation cardiomyocytes, but was restored by angiopoietin-1 treatment through integrin-beta1-mediated extracellular signal-regulated kinase and caspase 9 phosphorylation.
Title: Angiopoietin-1 protects heart against ischemia/reperfusion injury through VE-cadherin dephosphorylation and myocardiac integrin-β1/ERK/caspase-9 phosphorylation cascade.
Mechanism by which diabetes contributes to blood retinal breakdown breakdown through proteolytic degradation of VE-cadherin.
Title: Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

RH128436 (e-PCR)
- UniSTS:211744

Cdh5 (e-PCR), detects polymorphism
- UniSTS:547636

MGI:3803003 (e-PCR)
- UniSTS:516588

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BMP receptor binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables fibrinogen binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor complex adaptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor complex adaptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor 2 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in adherens junction organization	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel maturation	ISO Inferred from Sequence Orthology more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to bicellular tight junction	ISO Inferred from Sequence Orthology more info
involved_in regulation of complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cadherin-5

Names: VE-cadherin; vascular endothelial cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107407.1 → NP_001100877.1 cadherin-5

See identical proteins and their annotated locations for NP_001100877.1

Status: PROVISIONAL

Source sequence(s)

CH474006

UniProtKB/TrEMBL

A6JXX3, F1M7E5

Conserved Domains (3) summary

cd11304
Location:145 → 244

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:69 → 139

CA; Cadherin repeats

pfam01049
Location:623 → 767

Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

821875..860931 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097688.2 → XP_038953616.1 cadherin-5 isoform X1

UniProtKB/TrEMBL

A0A0G2K0I6, F1M7E5

Related

ENSRNOP00000017983.8, ENSRNOT00000017983.8

Conserved Domains (3) summary

cd11304
Location:145 → 244

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:69 → 139

CA; Cadherin repeats

pfam01049
Location:619 → 770

Cadherin_C; Cadherin cytoplasmic region
XM_039097689.2 → XP_038953617.1 cadherin-5 isoform X1

UniProtKB/TrEMBL

A0A0G2K0I6, F1M7E5

Conserved Domains (3) summary

cd11304
Location:145 → 244

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:69 → 139

CA; Cadherin repeats

pfam01049
Location:619 → 770

Cadherin_C; Cadherin cytoplasmic region