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    Rbis ribosomal biogenesis factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499567, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbisprovided by RGD
    Official Full Name
    ribosomal biogenesis factorprovided by RGD
    Primary source
    RGD:1565641
    See related
    EnsemblRapid:ENSRNOG00000064945 AllianceGenome:RGD:1565641
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565641
    Summary
    Predicted to be involved in ribosome biogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleolus. Orthologous to human RBIS (ribosomal biogenesis factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 249.7), Kidney (RPKM 205.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbis in Genome Data Viewer
    Location:
    2q23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (88702599..88718587)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (86981314..86997352)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (88338018..88350785)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 1 Neighboring gene carbonic anhydrase 13 Neighboring gene peroxiredoxin like 2A, pseudogene 1 Neighboring gene transfer RNA proline (anticodon AGG) Neighboring gene E2F transcription factor 5 Neighboring gene leucine rich repeat and coiled-coil centrosomal protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells. Badertscher L, et al. Cell Rep, 2015 Dec 29. PMID 26711351
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal biogenesis factor
    Names
    uncharacterized protein C8orf59 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109179.1 → NP_001102649.1  ribosomal biogenesis factor

      See identical proteins and their annotated locations for NP_001102649.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473961
      UniProtKB/TrEMBL
      A6IH16
      Conserved Domains (1) summary
      pfam15679
      Location:1 → 97
      DUF4665; Domain of unknown function (DUF4665)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      88702599..88718587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232114.5 → XP_006232176.1  ribosomal biogenesis factor isoform X3

      See identical proteins and their annotated locations for XP_006232176.1

      UniProtKB/TrEMBL
      A6IH16
      Related
      ENSRNOP00000094002.2, ENSRNOT00000095275.2
      Conserved Domains (1) summary
      pfam15679
      Location:1 → 97
      DUF4665; Domain of unknown function (DUF4665)

    2. XM_039102857.2 → XP_038958785.1  ribosomal biogenesis factor isoform X3

      UniProtKB/TrEMBL
      A6IH16
      Conserved Domains (1) summary
      pfam15679
      Location:1 → 97
      DUF4665; Domain of unknown function (DUF4665)

    3. XM_039102855.2 → XP_038958783.1  ribosomal biogenesis factor isoform X2

      UniProtKB/TrEMBL
      D3ZXR6
      Conserved Domains (1) summary
      pfam15679
      Location:56 → 152
      DUF4665; Domain of unknown function (DUF4665)

    4. XM_039102854.2 → XP_038958782.1  ribosomal biogenesis factor isoform X1

      Related
      ENSRNOP00000056222.4, ENSRNOT00000059467.6
      Conserved Domains (1) summary
      pfam15679
      Location:64 → 160
      DUF4665; Domain of unknown function (DUF4665)
    Nucleotide Protein Strain
    Heading Accession and Version

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