Kcna2 potassium voltage-gated channel subfamily A member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcna2provided by RGD
Official Full Name: potassium voltage-gated channel subfamily A member 2provided by RGD
Primary source: RGD:2950
See related: EnsemblRapid:ENSRNOG00000018285 AllianceGenome:RGD:2950
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BK2; NGK1
Summary: Enables kinesin binding activity and voltage-gated monoatomic ion channel activity. Involved in several processes, including nervous system development; neuronal action potential; and potassium ion export across plasma membrane. Located in juxtaparanode region of axon; lamellipodium; and plasma membrane. Part of voltage-gated potassium channel complex. Is active in calyx of Held; glutamatergic synapse; and synaptic membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 32. Orthologous to human KCNA2 (potassium voltage-gated channel subfamily A member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 198.8), Heart (RPKM 71.5) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (197392746..197406606)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (194704555..194718387)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (209838607..209852471)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of ubiquitin conjugating enzyme E2B (Ube2b) ameliorates neuropathic pain by regulating Kcna2 (potassium voltage-gated channel subfamily A member 2) in primary afferent neurons.
Title: Upregulation of ubiquitin conjugating enzyme E2B (Ube2b) ameliorates neuropathic pain by regulating Kcna2 (potassium voltage-gated channel subfamily A member 2) in primary afferent neurons.
Epigenetic restoration of voltage-gated potassium channel Kv1.2 alleviates nerve injury-induced neuropathic pain.
Title: Epigenetic restoration of voltage-gated potassium channel Kv1.2 alleviates nerve injury-induced neuropathic pain.
two residues E327 and H418 in the proximity of the water cavity of Kv1.2 play crucial roles as a pH switch
Title: Structural and molecular insight into the pH-induced low-permeability of the voltage-gated potassium channel Kv1.2 through dewetting of the water cavity.
The expression of KCNA2 is decreased in the DRG neurons of rats with OA pain likely as a result of enhanced methylation of Kcna2 promoter region
Title: [Expression of KCNA2 in the dorsal root ganglia of rats with osteoarthritis pain induced by monoiodoacetate].
indings suggest that increased dorsal horn DNMT3a contributes to bone cancer pain through silencing dorsal horn Kv1.2 expression
Title: DNMT3a contributes to the development and maintenance of bone cancer pain by silencing Kv1.2 expression in spinal cord dorsal horn.
Ventricular Kcna2 AS expression increases in rats with CHF and contributes to reduced IKs, prolonged APs, and the occurrence of ventricular arrhythmias by silencing Kcna2.
Title: Long Noncoding RNA Kcna2 Antisense RNA Contributes to Ventricular Arrhythmias via Silencing Kcna2 in Rats With Congestive Heart Failure.
Data indicate that in cryo-electron microscopy (cryo-EM) images of the relatively small Kv1.2 channel complex, the protein particle's contribution is quite weak compared to the membrane density.
Title: Statistical modeling and removal of lipid membrane projections for cryo-EM structure determination of reconstituted membrane proteins.
the dynamics of the ion conduction processes in the Kv1.2 pore domain
Title: Ion Concentration- and Voltage-Dependent Push and Pull Mechanisms of Potassium Channel Ion Conduction.
Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 pyramidal cells
Title: Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 pyramidal cells.
An R300C mutation creates a large cavity in the voltage sensing domain.
Title: Caution is required in interpretation of mutations in the voltage sensing domain of voltage gated channels as evidence for gating mechanisms.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

KCNA2_869 (e-PCR)
- UniSTS:277404

KCNA2_V168 (e-PCR)
- UniSTS:277404

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables delayed rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables outward rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	NAS Non-traceable Author Statement more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in corpus callosum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in optic nerve development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within optic nerve structural organization	ISO Inferred from Sequence Orthology more info
involved_in potassium ion export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian sleep/wake cycle, non-REM sleep	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in axon initial segment	ISO Inferred from Sequence Orthology more info
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in calyx of Held	EXP Inferred from Experiment more info	PubMed
is_active_in calyx of Held	IDA Inferred from Direct Assay more info	PubMed
is_active_in calyx of Held	NAS Non-traceable Author Statement more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in juxtaparanode region of axon	IBA Inferred from Biological aspect of Ancestor more info
located_in juxtaparanode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in paranodal junction	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily A member 2

Names: Potassium (K+) channel protein alpha 2, voltage dependent; Potassium voltage gated channel shaker related subfamily member 2; RAK; RBK2; RCK5; potassium channel, voltage gated shaker related subfamily A, member 2; potassium voltage-gated channel, shaker-related subfamily, member 2; voltage-gated potassium channel subunit Kv1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012970.4 → NP_037102.1 potassium voltage-gated channel subfamily A member 2

See identical proteins and their annotated locations for NP_037102.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P63142

UniProtKB/TrEMBL

A6HUS5

Conserved Domains (2) summary

cl38908
Location:33 → 159

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:162 → 420

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

197392746..197406606

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233133.5 → XP_006233195.1 potassium voltage-gated channel subfamily A member 2 isoform X1

See identical proteins and their annotated locations for XP_006233195.1

UniProtKB/Swiss-Prot

P63142

UniProtKB/TrEMBL

A6HUS5

Related

ENSRNOP00000089201.1, ENSRNOT00000100022.2

Conserved Domains (2) summary

cl38908
Location:33 → 159

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:162 → 420

Ion_trans; Ion transport protein
XM_063281363.1 → XP_063137433.1 potassium voltage-gated channel subfamily A member 2 isoform X1

UniProtKB/Swiss-Prot

P63142

UniProtKB/TrEMBL

A6HUS5
XM_006233134.5 → XP_006233196.1 potassium voltage-gated channel subfamily A member 2 isoform X1

See identical proteins and their annotated locations for XP_006233196.1

UniProtKB/Swiss-Prot

P63142

UniProtKB/TrEMBL

A6HUS5

Related

ENSRNOP00000079590.1, ENSRNOT00000108979.2

Conserved Domains (2) summary

cl38908
Location:33 → 159

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:162 → 420

Ion_trans; Ion transport protein
XM_063281362.1 → XP_063137432.1 potassium voltage-gated channel subfamily A member 2 isoform X1

UniProtKB/Swiss-Prot

P63142

UniProtKB/TrEMBL

A6HUS5
XM_008761371.4 → XP_008759593.1 potassium voltage-gated channel subfamily A member 2 isoform X1

See identical proteins and their annotated locations for XP_008759593.1

UniProtKB/Swiss-Prot

P63142

UniProtKB/TrEMBL

A6HUS5

Conserved Domains (2) summary

cl38908
Location:33 → 159

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:162 → 420

Ion_trans; Ion transport protein
XM_063281364.1 → XP_063137434.1 potassium voltage-gated channel subfamily A member 2 isoform X1

UniProtKB/Swiss-Prot

P63142

UniProtKB/TrEMBL

A6HUS5
XM_006233132.5 → XP_006233194.1 potassium voltage-gated channel subfamily A member 2 isoform X1

See identical proteins and their annotated locations for XP_006233194.1

UniProtKB/Swiss-Prot

P63142

UniProtKB/TrEMBL

A6HUS5

Related

ENSRNOP00000090952.1, ENSRNOT00000116262.2

Conserved Domains (2) summary

cl38908
Location:33 → 159

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:162 → 420

Ion_trans; Ion transport protein
XM_039101797.2 → XP_038957725.1 potassium voltage-gated channel subfamily A member 2 isoform X1

UniProtKB/Swiss-Prot

P63142

UniProtKB/TrEMBL

A6HUS5

Conserved Domains (2) summary

cl38908
Location:33 → 159

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:162 → 420

Ion_trans; Ion transport protein
XM_039101795.2 → XP_038957723.1 potassium voltage-gated channel subfamily A member 2 isoform X1

UniProtKB/Swiss-Prot

P63142

UniProtKB/TrEMBL

A6HUS5

Conserved Domains (2) summary

cl38908
Location:33 → 159

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:162 → 420

Ion_trans; Ion transport protein