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    Arhgap29 Rho GTPase activating protein 29 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310833, updated on 9-Dec-2024

    Summary

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    Symbol
    Arhgap29provided by RGD
    Full Name
    Rho GTPase activating protein 29provided by RGD
    Primary source
    RGD:1306185
    See related
    EnsemblRapid:ENSRNOG00000012563 AllianceGenome:RGD:1306185
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306185; B130017i01rik
    Summary
    Predicted to enable GTPase activator activity and PDZ domain binding activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human ARHGAP29 (Rho GTPase activating protein 29). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 367.4), Kidney (RPKM 232.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap29 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (212744626..212816710)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (210060036..210132572)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (225552075..225613349)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350100 Neighboring gene uncharacterized LOC134485959 Neighboring gene uncharacterized LOC108350286 Neighboring gene ATP binding cassette subfamily A member 4 Neighboring gene uncharacterized LOC102555028

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity. de Kreuk BJ, et al. Elife, 2016 Jan 19. PMID 26780829, Free PMC Article
    2. KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. Ahmed SM, et al. J Cell Biol, 2012 Dec 10. PMID 23209302, Free PMC Article
    3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95332

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 29
    Names
    PTPL1-associated RhoGAP 1
    rho-type GTPase-activating protein 29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009405.1 → NP_001009405.1  rho GTPase-activating protein 29

      See identical proteins and their annotated locations for NP_001009405.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087167
      UniProtKB/TrEMBL
      A0A8I6ADH0
      Related
      ENSRNOP00000062636.2, ENSRNOT00000066486.5
      Conserved Domains (3) summary
      smart00109
      Location:525 → 570
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cl02570
      Location:582 → 794
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:131 → 347
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      212744626..212816710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102436.2 → XP_038958364.1  rho GTPase-activating protein 29 isoform X1

      UniProtKB/Swiss-Prot
      Q5PQJ5
      UniProtKB/TrEMBL
      A6HVF6
      Conserved Domains (3) summary
      cd20816
      Location:613 → 663
      C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family
      cl02570
      Location:671 → 883
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:220 → 436
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_006233240.5 → XP_006233302.1  rho GTPase-activating protein 29 isoform X1

      See identical proteins and their annotated locations for XP_006233302.1

      UniProtKB/Swiss-Prot
      Q5PQJ5
      UniProtKB/TrEMBL
      A6HVF6
      Conserved Domains (3) summary
      cd20816
      Location:613 → 663
      C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family
      cl02570
      Location:671 → 883
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:220 → 436
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_039102437.2 → XP_038958365.1  rho GTPase-activating protein 29 isoform X1

      UniProtKB/Swiss-Prot
      Q5PQJ5
      UniProtKB/TrEMBL
      A6HVF6
      Conserved Domains (3) summary
      cd20816
      Location:613 → 663
      C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family
      cl02570
      Location:671 → 883
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:220 → 436
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. XM_006233239.5 → XP_006233301.1  rho GTPase-activating protein 29 isoform X1

      See identical proteins and their annotated locations for XP_006233301.1

      UniProtKB/Swiss-Prot
      Q5PQJ5
      UniProtKB/TrEMBL
      A6HVF6
      Conserved Domains (3) summary
      cd20816
      Location:613 → 663
      C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family
      cl02570
      Location:671 → 883
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:220 → 436
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. XM_039102440.2 → XP_038958368.1  rho GTPase-activating protein 29 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADH0
      Related
      ENSRNOP00000106014.1, ENSRNOT00000168211.1
      Conserved Domains (3) summary
      cd20816
      Location:549 → 599
      C1_GMIP-like; protein kinase C conserved region 1 (C1 domain) found in the GEM-interacting protein (GMIP)-like family
      cl02570
      Location:607 → 819
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:156 → 372
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. XM_063281944.1 → XP_063138014.1  rho GTPase-activating protein 29 isoform X1

      UniProtKB/Swiss-Prot
      Q5PQJ5
      UniProtKB/TrEMBL
      A6HVF6
      Related
      ENSRNOP00000017076.6, ENSRNOT00000017076.7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQJ5.2 GenPept UniProtKB/Swiss-Prot:Q5PQJ5

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