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    Adgrl4 adhesion G protein-coupled receptor L4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64124, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgrl4provided by RGD
    Official Full Name
    adhesion G protein-coupled receptor L4provided by RGD
    Primary source
    RGD:621136
    See related
    EnsemblRapid:ENSRNOG00000033940 AllianceGenome:RGD:621136
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Etl; Eltd1
    Summary
    Predicted to enable G protein-coupled receptor activity. Involved in protein-containing complex assembly. Located in cytoplasmic vesicle and plasma membrane. Biomarker of glioblastoma. Orthologous to human ADGRL4 (adhesion G protein-coupled receptor L4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 175.8), Kidney (RPKM 171.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adgrl4 in Genome Data Viewer
    Location:
    2q45
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (243014927..243117226)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (240354909..240457231)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (256609787..256724642)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691735 Neighboring gene uncharacterized LOC134486008 Neighboring gene uncharacterized LOC102548445 Neighboring gene interferon-induced protein 44

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models. Ziegler J, et al. Neuro Oncol, 2017 Feb 1. PMID 27416955, Free PMC Article
    2. ELTD1, a potential new biomarker for gliomas. Towner RA, et al. Neurosurgery, 2013 Jan. PMID 23096411, Free PMC Article
    3. Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1. Xiao J, et al. PLoS One, 2012. PMID 22606234, Free PMC Article
    4. ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. Nechiporuk T, et al. J Biol Chem, 2001 Feb 9. PMID 11050079
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor L4
    Names
    EGF, latrophilin and seven transmembrane domain containing 1
    EGF, latrophilin and seven transmembrane domain-containing protein 1
    EGF, latrophilin seven transmembrane domain containing 1
    EGF-TM7-latrophilin-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022294.1 → NP_071630.1  adhesion G protein-coupled receptor L4 precursor

      See identical proteins and their annotated locations for NP_071630.1

      Status: PROVISIONAL

      Source sequence(s)
      AF192401
      UniProtKB/Swiss-Prot
      Q9ESC0, Q9ESC1
      UniProtKB/TrEMBL
      A0A8L2R476, A6HWI6
      Related
      ENSRNOP00000045890.4, ENSRNOT00000047564.6
      Conserved Domains (4) summary
      smart00179
      Location:57 → 90
      EGF_CA; Calcium-binding EGF-like domain
      pfam01825
      Location:416 → 460
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:188 → 365
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl21561
      Location:472 → 708
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      243014927..243117226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103036.2 → XP_038958964.1  adhesion G protein-coupled receptor L4 isoform X1

      UniProtKB/TrEMBL
      A0A8L2R476
      Related
      ENSRNOP00000107605.1, ENSRNOT00000155090.1
      Conserved Domains (5) summary
      smart00179
      Location:57 → 90
      EGF_CA; Calcium-binding EGF-like domain
      pfam01825
      Location:366 → 410
      GPS; GPCR proteolysis site, GPS, motif
      pfam16489
      Location:136 → 312
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:424 → 449
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:422 → 679
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESC1.1 GenPept UniProtKB/Swiss-Prot:Q9ESC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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