Aire autoimmune regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aireprovided by RGD
Official Full Name: autoimmune regulatorprovided by RGD
Primary source: RGD:1311139
See related: EnsemblRapid:ENSRNOG00000001213 AllianceGenome:RGD:1311139
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including histone binding activity; identical protein binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including immune system development; negative thymic T cell selection; and positive regulation of macromolecule biosynthetic process. Predicted to be located in cytoplasm; germ cell nucleus; and nuclear body. Predicted to be active in nucleus. Used to study autoimmune polyendocrine syndrome. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 9.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (10635775..10650709)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (10636058..10651060)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (11365630..11380636)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D20Ztm3 (e-PCR)
- UniSTS:517941

D20Got10 (e-PCR)
- UniSTS:113006

d20rat67 (e-PCR)
- UniSTS:121574

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables translation regulator activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in central tolerance induction to self antigen	IBA Inferred from Biological aspect of Ancestor more info
involved_in central tolerance induction to self antigen	ISO Inferred from Sequence Orthology more info
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within humoral immune response	ISO Inferred from Sequence Orthology more info
involved_in negative thymic T cell selection	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative thymic T cell selection	ISO Inferred from Sequence Orthology more info
involved_in peripheral T cell tolerance induction	IBA Inferred from Biological aspect of Ancestor more info
involved_in peripheral T cell tolerance induction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of thymocyte migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of thymocyte migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in thymus epithelium morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in thymus epithelium morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in female germ cell nucleus	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: autoimmune regulator

Names: autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106379.1 → NP_001099849.1 autoimmune regulator isoform 2

See identical proteins and their annotated locations for NP_001099849.1

Status: PROVISIONAL

Source sequence(s)

CH473988

UniProtKB/TrEMBL

A6JK47

Conserved Domains (4) summary

cd15539
Location:296 → 338

PHD1_AIRE; PHD finger 1 found in autoimmune regulator (AIRE)

cd15540
Location:429 → 471

PHD2_AIRE; PHD finger 2 found in autoimmune regulator (AIRE)

pfam03172
Location:17 → 103

Sp100; Sp100 domain

cl02536
Location:198 → 264

SAND; SAND domain
NM_001434617.1 → NP_001421546.1 autoimmune regulator isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

D3ZV49

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

10635775..10650709

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256247.4 → XP_006256309.1 autoimmune regulator isoform X1

Related

ENSRNOP00000001611.4, ENSRNOT00000001611.6

Conserved Domains (4) summary

cd15539
Location:300 → 342

PHD1_AIRE; PHD finger 1 found in autoimmune regulator (AIRE)

cd15540
Location:433 → 475

PHD2_AIRE; PHD finger 2 found in autoimmune regulator (AIRE)

pfam03172
Location:17 → 103

Sp100; Sp100 domain

cl02536
Location:198 → 264

SAND; SAND domain
XM_063279044.1 → XP_063135114.1 autoimmune regulator isoform X4

UniProtKB/TrEMBL

A0A8I5ZTP2

Related

ENSRNOP00000082176.1, ENSRNOT00000106293.2
XM_063279042.1 → XP_063135112.1 autoimmune regulator isoform X2
XM_063279045.1 → XP_063135115.1 autoimmune regulator isoform X5
XM_063279046.1 → XP_063135116.1 autoimmune regulator isoform X6

UniProtKB/TrEMBL

A6JK48
XM_063279043.1 → XP_063135113.1 autoimmune regulator isoform X3
XM_063279047.1 → XP_063135117.1 autoimmune regulator isoform X7
XM_017601599.3 → XP_017457088.1 autoimmune regulator isoform X8

UniProtKB/TrEMBL

A0A8I6AL71

Related

ENSRNOP00000094625.1, ENSRNOT00000113259.2
XM_063279048.1 → XP_063135118.1 autoimmune regulator isoform X9
XM_017601601.3 → XP_017457090.1 autoimmune regulator isoform X10

UniProtKB/TrEMBL

A6JK49

Conserved Domains (4) summary

cd15539
Location:296 → 338

PHD1_AIRE; PHD finger 1 found in autoimmune regulator (AIRE)

pfam03172
Location:17 → 103

Sp100; Sp100 domain

cl02536
Location:198 → 264

SAND; SAND domain

cl02608
Location:316 → 377

BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
XM_063279049.1 → XP_063135119.1 autoimmune regulator isoform X11