Tff2 trefoil factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tff2provided by RGD
Official Full Name: trefoil factor 2provided by RGD
Primary source: RGD:620709
See related: EnsemblRapid:ENSRNOG00000001162 AllianceGenome:RGD:620709
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable CXCR4 chemokine receptor binding activity. Predicted to be involved in chemokine-mediated signaling pathway; maintenance of gastrointestinal epithelium; and negative regulation of gastric acid secretion. Predicted to act upstream of or within several processes, including calcium-mediated signaling; negative regulation of macrophage activation; and positive regulation of ERK1 and ERK2 cascade. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human TFF2 (trefoil factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 173.4) and Liver (RPKM 65.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (9217110..9220979, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (9215750..9219619, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (9872669..9876008, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Substantial amounts of TFF1 were detected only in the cytoplasm of epithelial cells in the submandibular glands granular convoluted tubules (GCT), while TFF2 and TFF3 were widely distributed in the cytoplasm of epithelial cells of intercalated ducts
Title: Expression and localization of trefoil factor family genes in rat submandibular glands.
iNOS-derived NO associated with NSAID-induced gastric injury is implicated in mucosal restitution via the HIF-1-mediated induction of TFF2 genes.
Title: iNOS-derived nitric oxide mediates the increase in TFF2 expression associated with gastric damage: role of HIF-1.
Esophageal intestinal-type mucosa was present at sacrifice in 18 animals. Compared to jejunum, the expression of TFF-1 and TFF-2 mRNA in the intestinal mucosa of the distal esophagus was increased.
Title: Validation of a rodent model of Barrett's esophagus using quantitative gene expression profiling.
TFF may not only participate in the early phase of epithelial repair known as restitution (maked by increased cell migration), but also play an important role in the subsequent, protracted phase of glandular renewal(made by cell proliferation).
Title: Role of TFF in healing of stress-induced gastric lesions.
Keratinocyte growth factor enhances TFF2 expression in proximal small bowel and increases goblet cell number and TFF3 protein content throughout the intestine independent of food intake
Title: Trefoil peptide expression and goblet cell number in rat intestine: effects of KGF and fasting-refeeding.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CXCR4 chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CXCR4 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables structural molecule activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of gastric acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in maintenance of gastrointestinal epithelium	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gastric acid secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of gastric acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: trefoil factor 2

Names: SP; spasmolytic polypeptide; trefoil factor 2 (spasmolytic protein 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053844.2 → NP_446296.2 trefoil factor 2 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

Q09030

UniProtKB/TrEMBL

A6JJY3, G3V643

Related

ENSRNOP00000001537.2, ENSRNOT00000001537.6

Conserved Domains (2) summary

smart00018
Location:79 → 124

PD; P or trefoil or TFF domain

pfam00088
Location:31 → 72

Trefoil; Trefoil (P-type) domain