Slc2a10 solute carrier family 2 member 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc2a10provided by RGD
Official Full Name: solute carrier family 2 member 10provided by RGD
Primary source: RGD:1306552
See related: EnsemblRapid:ENSRNOG00000025384 AllianceGenome:RGD:1306552
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and symporter activity. Predicted to be involved in D-glucose import across plasma membrane; circulatory system development; and dehydroascorbic acid transport. Predicted to act upstream of or within several processes, including cell redox homeostasis; regulation of macromolecule biosynthetic process; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in arterial tortuosity syndrome. Orthologous to human SLC2A10 (solute carrier family 2 member 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 33.4), Uterus (RPKM 14.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (174659683..174671978)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (154240395..154252690)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (162182156..162194610)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dehydroascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in D-glucose import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in D-glucose transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within artery development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell redox homeostasis	ISO Inferred from Sequence Orthology more info
involved_in circulatory system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in dehydroascorbic acid transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal joint development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of connective tissue growth factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of extracellular matrix organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 10

Names: solute carrier family 2 (facilitated glucose transporter), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108963.1 → NP_001102433.1 solute carrier family 2, facilitated glucose transporter member 10

See identical proteins and their annotated locations for NP_001102433.1

Status: PROVISIONAL

Source sequence(s)

CH474005

UniProtKB/TrEMBL

A0A8I6ADR5, A6JXF7

Related

ENSRNOP00000090543.1, ENSRNOT00000109062.2

Conserved Domains (2) summary

cd06174
Location:14 → 330

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:11 → 508

Sugar_tr; Sugar (and other) transporter