Traf2 Tnf receptor-associated factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Traf2provided by RGD
Official Full Name: Tnf receptor-associated factor 2provided by RGD
Primary source: RGD:1310457
See related: EnsemblRapid:ENSRNOG00000006238 AllianceGenome:RGD:1310457
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in negative regulation of glial cell apoptotic process; positive regulation of NF-kappaB transcription factor activity; and tumor necrosis factor-mediated signaling pathway. Located in cell cortex. Part of protein-containing complex. Orthologous to human TRAF2 (TNF receptor associated factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 176.1), Testes (RPKM 148.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28740098..28764752, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (8341950..8366609, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2746061..2770690, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studied the effect of gastrodin (GAS) on LT, and found the endoplasmic reticulum to nucleus signaling 1(IRE1alpha)/Tnf receptor-associated factor 2 (TRAF2)/NF-kappaB signal pathway (and therefore acute rejection) was suppressed by GAS.
Title: Gastrodin Ameliorates Acute Rejection via IRE1α/TRAF2/NF-κB in Rats Receiving Liver Allografts.
Our data suggest that upregulation of TRAF2 triggered by trauma plays an important role in suppressing neuronal apoptosis after spinal cord injury
Title: Up-regulation of TRAF2 Suppresses Neuronal Apoptosis after Rat Spinal Cord Injury.
Curcumin decreased TNFR2 and increased TRAF2 to decrease the apoptotic pathway in ureteral obstruction rats.
Title: Effect of curcumin on TNFR2 and TRAF2 in unilateral ureteral obstruction in rats.
IL-1beta and IFNgamma upregulate the expression of TRAF2 in insulin-producing INS-1E cells and isolated rat pancreatic islets.
Title: TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells.
Data suggest that TRAF-2 could induce the proinflammatory and proliferative effects of soluble aggregated IgG on rat mesangial cells.
Title: Suppression of tumor necrosis factor receptor associated factor (TRAF)-2 attenuates the proinflammatory and proliferative effect of aggregated IgG on rat renal mesangial cells.
Dominant-negative forms of TRAF2 and TRAF3 inhibited but did not fully block LMP1-mediated transformation.
Title: Unique signaling properties of CTAR1 in LMP1-mediated transformation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:224846 (e-PCR)
- UniSTS:224846

RH131098 (e-PCR)
- UniSTS:214381

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CD40 receptor binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables sphingolipid binding	ISO Inferred from Sequence Orthology more info
enables thioesterase binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CD27 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in CD40 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in TORC1 complex assembly	ISO Inferred from Sequence Orthology more info
involved_in TORC2 complex disassembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to nitric oxide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect innate immune response	ISO Inferred from Sequence Orthology more info
involved_in interleukin-17-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within programmed necrotic cell death	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction involved in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CD40 receptor complex	ISO Inferred from Sequence Orthology more info
part_of IRE1-TRAF2-ASK1 complex	ISO Inferred from Sequence Orthology more info
part_of IRE1-TRAF2-ASK1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of TRAF2-GSTP1 complex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
part_of plasma membrane signaling receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of tumor necrosis factor receptor superfamily complex	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TNF receptor-associated factor 2

NP_001101285.1

EC 2.3.2.27

XP_006233656.1

EC 2.3.2.27

XP_006233658.1

EC 2.3.2.27

XP_008759810.1

EC 2.3.2.27

XP_038961110.1

EC 2.3.2.27

XP_038961111.1

EC 2.3.2.27

XP_063139987.1

EC 2.3.2.27

XP_063139988.1

EC 2.3.2.27

XP_063139989.1

EC 2.3.2.27

XP_063139990.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107815.2 → NP_001101285.1 TNF receptor-associated factor 2

See identical proteins and their annotated locations for NP_001101285.1

Status: PROVISIONAL

Source sequence(s)

BC169064

UniProtKB/TrEMBL

A0A9K3Y7P7, B5DFH7, E9PSP4

Conserved Domains (4) summary

cd03778
Location:330 → 493

MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:178 → 234

zf-TRAF; TRAF-type zinc finger

cd16639
Location:32 → 73

RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins

pfam16673
Location:265 → 325

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

28740098..28764752 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233596.5 → XP_006233658.1 TNF receptor-associated factor 2 isoform X2

Conserved Domains (4) summary

cd03778
Location:276 → 439

MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:124 → 180

zf-TRAF; TRAF-type zinc finger

cd16639
Location:32 → 73

RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins

pfam16673
Location:211 → 271

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
XM_063283919.1 → XP_063139989.1 TNF receptor-associated factor 2 isoform X2
XM_006233594.5 → XP_006233656.1 TNF receptor-associated factor 2 isoform X1

See identical proteins and their annotated locations for XP_006233656.1

UniProtKB/TrEMBL

A0A9K3Y7P7, B5DFH7, E9PSP4

Conserved Domains (4) summary

cd03778
Location:330 → 493

MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:178 → 234

zf-TRAF; TRAF-type zinc finger

cd16639
Location:32 → 73

RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins

pfam16673
Location:265 → 325

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
XM_063283920.1 → XP_063139990.1 TNF receptor-associated factor 2 isoform X2
XM_008761588.4 → XP_008759810.1 TNF receptor-associated factor 2 isoform X1

See identical proteins and their annotated locations for XP_008759810.1

UniProtKB/TrEMBL

A0A9K3Y7P7, B5DFH7, E9PSP4

Related

ENSRNOP00000008253.7, ENSRNOT00000008253.8

Conserved Domains (4) summary

cd03778
Location:330 → 493

MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:178 → 234

zf-TRAF; TRAF-type zinc finger

cd16639
Location:32 → 73

RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins

pfam16673
Location:265 → 325

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
XM_063283918.1 → XP_063139988.1 TNF receptor-associated factor 2 isoform X1

UniProtKB/TrEMBL

A0A9K3Y7P7, B5DFH7, E9PSP4
XM_039105182.2 → XP_038961110.1 TNF receptor-associated factor 2 isoform X1

UniProtKB/TrEMBL

A0A9K3Y7P7, B5DFH7, E9PSP4

Conserved Domains (4) summary

cd03778
Location:330 → 493

MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:178 → 234

zf-TRAF; TRAF-type zinc finger

cd16639
Location:32 → 73

RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins

pfam16673
Location:265 → 325

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
XM_039105183.2 → XP_038961111.1 TNF receptor-associated factor 2 isoform X1

UniProtKB/TrEMBL

A0A9K3Y7P7, B5DFH7, E9PSP4

Conserved Domains (4) summary

cd03778
Location:330 → 493

MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:178 → 234

zf-TRAF; TRAF-type zinc finger

cd16639
Location:32 → 73

RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins

pfam16673
Location:265 → 325

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
XM_063283917.1 → XP_063139987.1 TNF receptor-associated factor 2 isoform X1

UniProtKB/TrEMBL

A0A9K3Y7P7, B5DFH7, E9PSP4