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    Ubac1 UBA domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362087, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubac1provided by RGD
    Official Full Name
    UBA domain containing 1provided by RGD
    Primary source
    RGD:1359542
    See related
    EnsemblRapid:ENSRNOG00000017983 AllianceGenome:RGD:1359542
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ubadc1
    Summary
    Predicted to enable polyubiquitin modification-dependent protein binding activity and proteasome binding activity. Predicted to be involved in protein maturation and protein ubiquitination. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be part of ubiquitin ligase complex. Orthologous to human UBAC1 (UBA domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 749.2), Heart (RPKM 288.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ubac1 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (29223582..29246216, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8825444..8848055, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (3453396..3476242, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene calmodulin regulated spectrin-associated protein 1 Neighboring gene ribosomal protein L8, pseudogene 7 Neighboring gene PIH1 domain containing 1, pseudogene 1 Neighboring gene uncharacterized LOC120101509 Neighboring gene NACC family member 2 Neighboring gene uncharacterized LOC103691752

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Kamura T, et al. Nat Cell Biol, 2004 Dec. PMID 15531880
    2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94349

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables polyubiquitin modification-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables proteasome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proteasome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-associated domain-containing protein 1
    Names
    E3 ubiquitin-protein ligase subunit KPC2
    UBA domain-containing protein 1
    kip1 ubiquitination-promoting complex protein 2
    ubiquitin associated domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007742.1 → NP_001007743.1  ubiquitin-associated domain-containing protein 1

      See identical proteins and their annotated locations for NP_001007743.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083603
      UniProtKB/Swiss-Prot
      Q5XIR9
      UniProtKB/TrEMBL
      A0A8I6GI40, A6JTB9
      Related
      ENSRNOP00000024352.3, ENSRNOT00000024352.6
      Conserved Domains (4) summary
      smart00727
      Location:357 → 396
      STI1; Heat shock chaperonin-binding motif
      cd14303
      Location:195 → 232
      UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cd14304
      Location:294 → 331
      UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cd17066
      Location:9 → 95
      Ubl_KPC2; ubiquitin-like (Ubl) domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      29223582..29246216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233689.3 → XP_006233751.1  ubiquitin-associated domain-containing protein 1 isoform X2

      Related
      ENSRNOP00000109139.1, ENSRNOT00000167041.1
      Conserved Domains (2) summary
      cd14303
      Location:195 → 232
      UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cl21463
      Location:294 → 325
      UBA_like_SF; UBA domain-like superfamily

    2. XM_039105357.1 → XP_038961285.1  ubiquitin-associated domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GI40
      Related
      ENSRNOP00000106592.1, ENSRNOT00000135533.1
      Conserved Domains (3) summary
      cd14303
      Location:195 → 232
      UBA1_KPC2; UBA1 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cd14304
      Location:294 → 331
      UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
      cd17066
      Location:9 → 95
      Ubl_KPC2; ubiquitin-like (Ubl) domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIR9.1 GenPept UniProtKB/Swiss-Prot:Q5XIR9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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