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    Kyat1 kynurenine aminotransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311844, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kyat1provided by RGD
    Official Full Name
    kynurenine aminotransferase 1provided by RGD
    Primary source
    RGD:1306912
    See related
    EnsemblRapid:ENSRNOG00000016097 AllianceGenome:RGD:1306912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gtk; Kat1; KatI; Ccbl1
    Summary
    Enables cysteine-S-conjugate beta-lyase activity and glutamine-phenylpyruvate transaminase activity. Involved in L-kynurenine metabolic process and pyruvate metabolic process. Predicted to be located in cytosol and mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human KYAT1 (kynurenine aminotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 733.3), Liver (RPKM 132.6) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kyat1 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33857407..33891153, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13459598..13493308, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8752289..8785617, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 13 Neighboring gene endonuclease G Neighboring gene SPOUT domain containing methyltransferase 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene leucine rich repeat containing 8 VRAC subunit A Neighboring gene uncharacterized LOC120101891 Neighboring gene phytanoyl-CoA dioxygenase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tissue expression and translational control of rat kynurenine aminotransferase/glutamine transaminase K mRNAs. Mosca M, et al. Biochim Biophys Acta, 2003 Jul 9. PMID 12850267
    2. Glutamine transaminase K and cysteine S-conjugate beta-lyase activity stains. Abraham DG, et al. Anal Biochem, 1991 Sep 2. PMID 1723851
    3. Molecular cloning of rat kynurenine aminotransferase: identity with glutamine transaminase K. Mosca M, et al. FEBS Lett, 1994 Oct 10. PMID 7926014
    4. Isolation and expression of a cDNA coding for rat kidney cytosolic cysteine conjugate beta-lyase. Perry SJ, et al. Mol Pharmacol, 1993 May. PMID 8502223
    5. Cloning and expression of a rat kidney cytosolic glutamine transaminase K that has strong sequence homology to kynurenine pyruvate aminotransferase. Abraham DG, et al. Arch Biochem Biophys, 1996 Nov 15. PMID 8914928

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. neuronal culture showed positive immunostaining for both kynurenic acid aminotransferase (KAT) isoforms I and II
      Title: Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in cultured cerebral cortical neurons.
    2. identification of presence in the permanent immature rat oligodendrocyte cell line OLN-93
      Title: Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in oligodendrocyte cell line (OLN-93).
    3. study demonstrated that several KATI mRNAs are constitutively expressed in ubiquitous manner; Each KATI mRNA exhibits a different in vitro translational efficiency, which corresponds to different levels of KAT enzymatic activity in transfected cells
      Title: Tissue expression and translational control of rat kynurenine aminotransferase/glutamine transaminase K mRNAs.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-S-conjugate beta-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-S-conjugate beta-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-S-conjugate beta-lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutamine-phenylpyruvate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kynurenine-oxoglutarate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kynurenine-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kynurenine-oxoglutarate transaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kynurenine-oxoglutarate transaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-kynurenine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-kynurenine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kynurenine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kynurenine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kynurenine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pyruvate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kynurenine--oxoglutarate transaminase 1
    Names
    cysteine conjugate-beta lyase 1
    cysteine conjugate-beta lyase, cytoplasmic
    cysteine-S-conjugate beta-lyase
    glutamine transaminase K
    glutamine--phenylpyruvate transaminase
    kynurenine aminotransferase I
    kynurenine aminotransferase/glutamine transaminase K
    kynurenine--oxoglutarate transaminase 1, mitochondrial
    kynurenine--oxoglutarate transaminase I
    XP_006233873.1
    XP_008759880.1
    XP_008759881.1
    XP_038961158.1
    XP_038961159.1
    XP_038961160.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013164.4 → NP_001013182.4  kynurenine--oxoglutarate transaminase 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q08415, Q9R096
      UniProtKB/TrEMBL
      A6JTW0
      Related
      ENSRNOP00000021865.4, ENSRNOT00000021865.8

    2. NM_001434248.1 → NP_001421177.1  kynurenine--oxoglutarate transaminase 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q08415, Q9R096
      UniProtKB/TrEMBL
      A6JTW0

    3. NM_001434249.1 → NP_001421178.1  kynurenine--oxoglutarate transaminase 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q08415, Q9R096

    4. NM_001434250.1 → NP_001421179.1  kynurenine--oxoglutarate transaminase 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q08415, Q9R096

    5. NM_001434251.1 → NP_001421180.1  kynurenine--oxoglutarate transaminase 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZSP9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      33857407..33891153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761658.3 → XP_008759880.1  kynurenine--oxoglutarate transaminase 1 isoform X1

      Conserved Domains (1) summary
      PRK08912
      Location:58 → 454
      PRK08912; aminotransferase

    2. XM_008761659.4 → XP_008759881.1  kynurenine--oxoglutarate transaminase 1 isoform X4

      UniProtKB/Swiss-Prot
      Q08415, Q9R096
      UniProtKB/TrEMBL
      A0A8I5ZZT5
      Related
      ENSRNOP00000085700.1, ENSRNOT00000102626.2
      Conserved Domains (1) summary
      cd00609
      Location:65 → 384
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...

    3. XM_039105232.2 → XP_038961160.1  kynurenine--oxoglutarate transaminase 1 isoform X5

      Conserved Domains (1) summary
      PRK08912
      Location:2 → 333
      PRK08912; aminotransferase

    4. XM_006233811.4 → XP_006233873.1  kynurenine--oxoglutarate transaminase 1 isoform X3

      Conserved Domains (2) summary
      cd00609
      Location:31 → 417
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PRK08912
      Location:24 → 420
      PRK08912; hypothetical protein; Provisional

    5. XM_039105231.2 → XP_038961159.1  kynurenine--oxoglutarate transaminase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q08415, Q9R096
      UniProtKB/TrEMBL
      A0A8I6AEE2
      Related
      ENSRNOP00000091831.1, ENSRNOT00000095192.2
      Conserved Domains (1) summary
      PRK08912
      Location:50 → 446
      PRK08912; aminotransferase

    6. XM_039105230.2 → XP_038961158.1  kynurenine--oxoglutarate transaminase 1 isoform X1

      Related
      ENSRNOP00000108587.1, ENSRNOT00000159811.1
      Conserved Domains (1) summary
      PRK08912
      Location:58 → 454
      PRK08912; aminotransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08415.2 GenPept UniProtKB/Swiss-Prot:Q08415

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