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    Atp8b4 ATPase phospholipid transporting 8B4 (putative) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311396, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp8b4provided by RGD
    Official Full Name
    ATPase phospholipid transporting 8B4 (putative)provided by RGD
    Primary source
    RGD:1306712
    See related
    EnsemblRapid:ENSRNOG00000031598 AllianceGenome:RGD:1306712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and magnesium ion binding activity. Predicted to be involved in lipid translocation and phospholipid transport. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be part of phospholipid-translocating ATPase complex. Orthologous to human ATP8B4 (ATPase phospholipid transporting 8B4 (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 60.5), Lung (RPKM 40.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp8b4 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (134008367..134212394, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (113554979..113757635, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (118591560..118968210, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 227, member B Neighboring gene fibroblast growth factor 7 Neighboring gene DTW domain containing 1 Neighboring gene U6 spliceosomal RNA Neighboring gene solute carrier family 27 member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. van der Velden LM, et al. J Biol Chem, 2010 Dec 17. PMID 20947505, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114491

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable phospholipid-transporting ATPase IM
    Names
    ATPase, class I, type 8B, member 4
    XP_038962769.1
    XP_038962770.1
    XP_038962771.1
    XP_038962772.1
    XP_038962774.1
    XP_038962775.1
    XP_038962776.1
    XP_038962778.1
    XP_038962779.1
    XP_063141379.1
    XP_063141380.1
    XP_063141382.1
    XP_063141383.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430434.1 → NP_001417363.1  probable phospholipid-transporting ATPase IM

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A1B0GWR9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      134008367..134212394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106842.2 → XP_038962770.1  probable phospholipid-transporting ATPase IM isoform X1

      Related
      ENSRNOP00000075998.2, ENSRNOT00000092750.3
      Conserved Domains (1) summary
      cd02073
      Location:31 → 975
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    2. XM_063285310.1 → XP_063141380.1  probable phospholipid-transporting ATPase IM isoform X2

    3. XM_039106844.2 → XP_038962772.1  probable phospholipid-transporting ATPase IM isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWR9
      Conserved Domains (1) summary
      cd02073
      Location:31 → 975
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    4. XM_039106846.2 → XP_038962774.1  probable phospholipid-transporting ATPase IM isoform X2

      Conserved Domains (1) summary
      cd02073
      Location:31 → 937
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    5. XM_039106847.2 → XP_038962775.1  probable phospholipid-transporting ATPase IM isoform X3

      Conserved Domains (1) summary
      cd02073
      Location:31 → 920
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    6. XM_039106841.2 → XP_038962769.1  probable phospholipid-transporting ATPase IM isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWR9
      Conserved Domains (1) summary
      cd02073
      Location:31 → 975
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    7. XM_063285309.1 → XP_063141379.1  probable phospholipid-transporting ATPase IM isoform X2

    8. XM_039106843.2 → XP_038962771.1  probable phospholipid-transporting ATPase IM isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWR9
      Conserved Domains (1) summary
      cd02073
      Location:31 → 975
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    9. XM_063285312.1 → XP_063141382.1  probable phospholipid-transporting ATPase IM isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZYK3

    10. XM_039106848.1 → XP_038962776.1  probable phospholipid-transporting ATPase IM isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZYK3
      Conserved Domains (1) summary
      cd02073
      Location:3 → 859
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    11. XM_039106851.1 → XP_038962779.1  probable phospholipid-transporting ATPase IM isoform X6

      UniProtKB/TrEMBL
      A6HPY3
      Conserved Domains (1) summary
      cl21460
      Location:14 → 520
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    12. XM_063285313.1 → XP_063141383.1  probable phospholipid-transporting ATPase IM isoform X7

    13. XM_039106850.2 → XP_038962778.1  probable phospholipid-transporting ATPase IM isoform X5

      Conserved Domains (1) summary
      cl21460
      Location:31 → 707
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025690.1: Suppressed sequence

      Description
      NM_001025690.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version

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