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    Peds1 plasmanylethanolamine desaturase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362278, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Peds1provided by RGD
    Official Full Name
    plasmanylethanolamine desaturase 1provided by RGD
    Primary source
    RGD:1309093
    See related
    AllianceGenome:RGD:1309093
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kua; Tmem189
    Summary
    Predicted to enable plasmanylethanolamine desaturase activity. Predicted to be involved in ether lipid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to several human genes including PEDS1 (plasmanylethanolamine desaturase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 177.4), Brain (RPKM 149.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Peds1 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (176769111..176788278, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (156350135..156369309, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (164376621..164388213, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486209 Neighboring gene uncharacterized LOC120101789 Neighboring gene uncharacterized LOC103691970 Neighboring gene ubiquitin conjugating enzyme E2 V1 Neighboring gene uncharacterized LOC120101790 Neighboring gene CCAAT/enhancer binding protein beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis. Gallego-García A, et al. Science, 2019 Oct 4. PMID 31604315
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables plasmanylethanolamine desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plasmanylethanolamine desaturase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ether lipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ether lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    plasmanylethanolamine desaturase 1
    Names
    Kua homolog
    transmembrane protein 189
    NP_001107224.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113752.1 → NP_001107224.1  plasmanylethanolamine desaturase 1

      See identical proteins and their annotated locations for NP_001107224.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158660
      UniProtKB/TrEMBL
      A0A0G2KB37, B0BN29
      Conserved Domains (1) summary
      pfam10520
      Location:86 → 262
      TMEM189_B_dmain; B domain of TMEM189, localization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      176769111..176788278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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