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    Slc25a26 solute carrier family 25 member 26 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362403, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc25a26provided by RGD
    Official Full Name
    solute carrier family 25 member 26provided by RGD
    Primary source
    RGD:1308811
    See related
    EnsemblRapid:ENSRNOG00000012831 AllianceGenome:RGD:1308811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity. Predicted to be involved in mitochondrial S-adenosyl-L-methionine transmembrane transport. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 28. Orthologous to human SLC25A26 (solute carrier family 25 member 26). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 110.6), Kidney (RPKM 43.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a26 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (128591223..128687854)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (127036704..127131026)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (126522335..126615402)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102171 Neighboring gene proteasome 20S subunit alpha 3, pseudogene 3 Neighboring gene leucine-rich repeats and immunoglobulin-like domains 1 Neighboring gene uncharacterized LOC134486819 Neighboring gene apolipoprotein O-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Intra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26. Kishita Y, et al. Am J Hum Genet, 2015 Nov 5. PMID 26522469, Free PMC Article
    2. Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution. Agrimi G, et al. Biochem J, 2004 Apr 1. PMID 14674884, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S-adenosyl-L-methionine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-adenosyl-L-methionine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in S-adenosyl-L-methionine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of macromolecule methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial S-adenosyl-L-methionine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial S-adenosylmethionine carrier protein
    Names
    S-adenosylmethionine mitochondrial carrier protein
    solute carrier family 25 (S-adenosylmethionine carrier), member 26
    solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395605.1 → NP_001382534.1  mitochondrial S-adenosylmethionine carrier protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AAR8, A6IBD8
      Related
      ENSRNOP00000089898.1, ENSRNOT00000111792.2
      Conserved Domains (1) summary
      PTZ00168
      Location:21 → 258
      PTZ00168; mitochondrial carrier protein; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      128591223..128687854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107818.2 → XP_038963746.1  mitochondrial S-adenosylmethionine carrier protein isoform X2

      UniProtKB/TrEMBL
      A6IBD8
      Conserved Domains (1) summary
      PTZ00168
      Location:21 → 206
      PTZ00168; mitochondrial carrier protein; Provisional

    2. XM_063286288.1 → XP_063142358.1  mitochondrial S-adenosylmethionine carrier protein isoform X6

    3. XM_039107819.2 → XP_038963747.1  mitochondrial S-adenosylmethionine carrier protein isoform X3

      Conserved Domains (1) summary
      PTZ00168
      Location:21 → 166
      PTZ00168; mitochondrial carrier protein; Provisional

    4. XM_039107817.2 → XP_038963745.1  mitochondrial S-adenosylmethionine carrier protein isoform X1

      UniProtKB/TrEMBL
      A6IBD8
      Related
      ENSRNOP00000059118.4, ENSRNOT00000065705.5
      Conserved Domains (1) summary
      PTZ00168
      Location:21 → 243
      PTZ00168; mitochondrial carrier protein; Provisional

    5. XM_039107820.2 → XP_038963748.1  mitochondrial S-adenosylmethionine carrier protein isoform X4

      Conserved Domains (2) summary
      PTZ00168
      Location:21 → 207
      PTZ00168; mitochondrial carrier protein; Provisional
      pfam00153
      Location:145 → 217
      Mito_carr; Mitochondrial carrier protein

    6. XM_039107823.2 → XP_038963751.1  mitochondrial S-adenosylmethionine carrier protein isoform X9

      Conserved Domains (1) summary
      pfam00153
      Location:22 → 82
      Mito_carr; Mitochondrial carrier protein

    7. XM_039107822.2 → XP_038963750.1  mitochondrial S-adenosylmethionine carrier protein isoform X8

      Conserved Domains (1) summary
      PTZ00168
      Location:3 → 170
      PTZ00168; mitochondrial carrier protein; Provisional

    8. XM_039107821.2 → XP_038963749.1  mitochondrial S-adenosylmethionine carrier protein isoform X6

      Conserved Domains (1) summary
      PTZ00168
      Location:21 → 166
      PTZ00168; mitochondrial carrier protein; Provisional

    9. XM_063286289.1 → XP_063142359.1  mitochondrial S-adenosylmethionine carrier protein isoform X7

      UniProtKB/TrEMBL
      A6IBD8

    10. XM_063286287.1 → XP_063142357.1  mitochondrial S-adenosylmethionine carrier protein isoform X5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108638.1: Suppressed sequence

      Description
      NM_001108638.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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