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    Iqub IQ motif and ubiquitin domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296936, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Iqubprovided by RGD
    Official Full Name
    IQ motif and ubiquitin domain containingprovided by RGD
    Primary source
    RGD:4145674
    See related
    EnsemblRapid:ENSRNOG00000021729 AllianceGenome:RGD:4145674
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Trs4; RGD1562359
    Summary
    Predicted to be involved in cilium assembly; flagellated sperm motility; and mating. Predicted to act upstream of or within smoothened signaling pathway. Predicted to be located in sperm flagellum. Predicted to be part of radial spoke. Predicted to be active in acrosomal vesicle and motile cilium. Orthologous to human IQUB (IQ motif and ubiquitin domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 251.2), Heart (RPKM 49.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Iqub in Genome Data Viewer
    Location:
    4q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (53897336..53962279, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (52931768..52993795, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (51482169..51586881, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 13 member 1 Neighboring gene thyroid hormone receptor associated protein 3, pseudogene 3 Neighboring gene inosine monophosphate dehydrogenase 2, pseudogene 1 Neighboring gene uncharacterized LOC108350676 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 Neighboring gene ankyrin repeat and SOCS box containing 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An NGF-induced Exo70-TC10 complex locally antagonises Cdc42-mediated activation of N-WASP to modulate neurite outgrowth. Pommereit D, et al. J Cell Sci, 2007 Aug 1. PMID 17635999
    2. Sorting nexin 9 interacts with dynamin 1 and N-WASP and coordinates synaptic vesicle endocytosis. Shin N, et al. J Biol Chem, 2007 Sep 28. PMID 17681954
    3. Identification of N-WASP homologs in human and rat brain. Fukuoka M, et al. Gene, 1997 Sep 1. PMID 9322739
    4. Male germ cell-specific protein Trs4 binds to multiple proteins. Shi YQ, et al. Biochem Biophys Res Commun, 2009 Oct 23. PMID 19706271
    5. Functional characterization of putative cilia genes by high-content analysis. Lai CK, et al. Mol Biol Cell, 2011 Apr. PMID 21289087, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggested that Trs4 might be involved in diverse processes of spermiogenesis and/or fertilization through interactions with its multiple binding partners.
      Title: Male germ cell-specific protein Trs4 binds to multiple proteins.
    2. findings confirm that the Exo70-TC10 complex mainly targets the NGF-induced Cdc42-dependent activation of N-WASP
      Title: An NGF-induced Exo70-TC10 complex locally antagonises Cdc42-mediated activation of N-WASP to modulate neurite outgrowth.
    3. SNX9 interacts with dynamin-1 and N-WASP in presynaptic terminals, where it links actin dynamics and synaptic vesicle endocytosis.
      Title: Sorting nexin 9 interacts with dynamin 1 and N-WASP and coordinates synaptic vesicle endocytosis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116166

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mating ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mating ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in 9+2 motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in 9+2 motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of radial spoke ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of radial spoke ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    IQ motif and ubiquitin-like domain-containing protein; IQ and ubiquitin-like domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034130.1 → NP_001029302.1  IQ motif and ubiquitin-like domain-containing protein

      See identical proteins and their annotated locations for NP_001029302.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099086
      UniProtKB/Swiss-Prot
      Q45GW3, Q4FZV4
      Related
      ENSRNOP00000063053.2, ENSRNOT00000064983.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      53897336..53962279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107272.2 → XP_038963200.1  IQ and ubiquitin-like domain-containing protein isoform X1

      Conserved Domains (1) summary
      cl28922
      Location:1 → 62
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_039107274.2 → XP_038963202.1  IQ and ubiquitin-like domain-containing protein isoform X2

    3. XM_063285735.1 → XP_063141805.1  IQ and ubiquitin-like domain-containing protein isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q45GW3.2 GenPept UniProtKB/Swiss-Prot:Q45GW3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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