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    Bach2 BTB domain and CNC homolog 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313125, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bach2provided by RGD
    Official Full Name
    BTB domain and CNC homolog 2provided by RGD
    Primary source
    RGD:1562865
    See related
    EnsemblRapid:ENSRNOG00000006170 AllianceGenome:RGD:1562865
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562865
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in import into nucleus; negative regulation of transcription by RNA polymerase II; and primary adaptive immune response involving T cells and B cells. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Human ortholog(s) of this gene implicated in immunodeficiency 60. Orthologous to human BACH2 (BTB domain and CNC homolog 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 52.9), Spleen (RPKM 50.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bach2 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (51428802..51779030)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (46632338..46982676)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (47458891..47807176)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134478955 Neighboring gene uncharacterized LOC120102849 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene uncharacterized LOC120102851 Neighboring gene gap junction protein, alpha 10 Neighboring gene caspase 8 associated protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency. Afzali B, et al. Nat Immunol, 2017 Jul. PMID 28530713, Free PMC Article
    2. Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Oyake T, et al. Mol Cell Biol, 1996 Nov. PMID 8887638, Free PMC Article
    3. Genome-wide RNAi screen for nuclear actin reveals a network of cofilin regulators. Dopie J, et al. J Cell Sci, 2015 Jul 1. PMID 26021350, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in primary adaptive immune response involving T cells and B cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription regulator protein BACH2
    Names
    BTB and CNC homology 1, basic leucine zipper transcription factor 2
    BTB and CNC homology 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135754.1 → NP_001129226.1  transcription regulator protein BACH2

      See identical proteins and their annotated locations for NP_001129226.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D3ZW33
      Related
      ENSRNOP00000090267.2, ENSRNOT00000113651.2
      Conserved Domains (2) summary
      cd14719
      Location:639 → 709
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18278
      Location:6 → 129
      BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      51428802..51779030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593349.3 → XP_017448838.1  transcription regulator protein BACH2 isoform X1

      UniProtKB/TrEMBL
      D3ZW33
      Conserved Domains (2) summary
      cd14719
      Location:639 → 709
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18278
      Location:6 → 129
      BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

    2. XM_017593345.3 → XP_017448834.1  transcription regulator protein BACH2 isoform X1

      UniProtKB/TrEMBL
      D3ZW33
      Related
      ENSRNOP00000063410.1, ENSRNOT00000065882.3
      Conserved Domains (2) summary
      cd14719
      Location:639 → 709
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18278
      Location:6 → 129
      BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

    3. XM_017593347.3 → XP_017448836.1  transcription regulator protein BACH2 isoform X1

      UniProtKB/TrEMBL
      D3ZW33
      Conserved Domains (2) summary
      cd14719
      Location:639 → 709
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18278
      Location:6 → 129
      BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

    4. XM_039109821.2 → XP_038965749.1  transcription regulator protein BACH2 isoform X1

      UniProtKB/TrEMBL
      D3ZW33
      Conserved Domains (2) summary
      cd14719
      Location:639 → 709
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18278
      Location:6 → 129
      BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

    5. XM_039109820.2 → XP_038965748.1  transcription regulator protein BACH2 isoform X1

      UniProtKB/TrEMBL
      D3ZW33
      Conserved Domains (2) summary
      cd14719
      Location:639 → 709
      bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
      cd18278
      Location:6 → 129
      BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

    RNA

    1. XR_010066378.1 RNA Sequence

    2. XR_005504432.2 RNA Sequence

    3. XR_010066379.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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