Luzp1 leucine zipper protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Luzp1provided by RGD
Official Full Name: leucine zipper protein 1provided by RGD
Primary source: RGD:61839
See related: EnsemblRapid:ENSRNOG00000022402 AllianceGenome:RGD:61839
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Luzp
Summary: Predicted to be involved in protein localization to actin cytoskeleton. Predicted to act upstream of or within artery development; neural fold bending; and ventricular septum development. Predicted to be located in nucleus. Predicted to be active in actin cytoskeleton and centrosome. Orthologous to human LUZP1 (leucine zipper protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 107.0), Kidney (RPKM 99.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (153989570..154065071)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (148706094..148781616)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (154831697..154907646)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leucine zipper protein 1 attenuates pressure overload-induced cardiac hypertrophy through inhibiting Stat3 signaling.
Title: Leucine zipper protein 1 attenuates pressure overload-induced cardiac hypertrophy through inhibiting Stat3 signaling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141759 (e-PCR)
- UniSTS:223752

Luzp1 (e-PCR), detects polymorphism
- UniSTS:525627

AW530660 (e-PCR)
- UniSTS:244551

RH141649 (e-PCR)
- UniSTS:223642

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in apical constriction	ISS Inferred from Sequence or Structural Similarity more info
involved_in artery development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within artery development	ISO Inferred from Sequence Orthology more info
involved_in contractile ring contraction	ISO Inferred from Sequence Orthology more info
involved_in contractile ring contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural fold bending	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural fold bending	ISO Inferred from Sequence Orthology more info
involved_in protein localization to actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein complex stability	ISS Inferred from Sequence or Structural Similarity more info
involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in ventricular septum development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ventricular septum development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CERF complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISS Inferred from Sequence or Structural Similarity more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info
located_in spindle midzone	ISS Inferred from Sequence or Structural Similarity more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISS Inferred from Sequence or Structural Similarity more info
located_in tight junction	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leucine zipper protein 1

Names: leucine zipper motif-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030830.2 → NP_110457.2 leucine zipper protein 1

See identical proteins and their annotated locations for NP_110457.2

Status: VALIDATED

Source sequence(s)

CH473968

UniProtKB/Swiss-Prot

Q9ESV1

UniProtKB/TrEMBL

A6ITB5, G3V7L9

Related

ENSRNOP00000016514.2, ENSRNOT00000016093.5

Conserved Domains (1) summary

COG1196
Location:10 → 348

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

153989570..154065071

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006239274.5 → XP_006239336.1 leucine zipper protein 1 isoform X1

See identical proteins and their annotated locations for XP_006239336.1

UniProtKB/Swiss-Prot

Q9ESV1

UniProtKB/TrEMBL

A6ITB5, G3V7L9

Conserved Domains (1) summary

COG1196
Location:10 → 348

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_063288465.1 → XP_063144535.1 leucine zipper protein 1 isoform X1

UniProtKB/Swiss-Prot

Q9ESV1

UniProtKB/TrEMBL

A6ITB5, G3V7L9
XM_063288466.1 → XP_063144536.1 leucine zipper protein 1 isoform X1

UniProtKB/Swiss-Prot

Q9ESV1

UniProtKB/TrEMBL

A6ITB5, G3V7L9