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    Fut9 fucosyltransferase 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fut9provided by RGD
    Official Full Name
    fucosyltransferase 9provided by RGD
    Primary source
    RGD:619955
    See related
    EnsemblRapid:ENSRNOG00000070149 AllianceGenome:RGD:619955
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity and protein homodimerization activity. Involved in nervous system development. Predicted to be located in trans-Golgi network membrane. Orthologous to human FUT9 (fucosyltransferase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 131.7), Uterus (RPKM 29.5) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fut9 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (44148371..44361209, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (39351815..39565256, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (40032855..40237591, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene igE-binding protein-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134478953 Neighboring gene mannosidase, endo-alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fucosyltransferase 9 promotes neuronal differentiation and functional recovery after spinal cord injury by suppressing the activation of Notch signaling. Chen J, et al. Acta Biochim Biophys Sin (Shanghai), 2023 Oct 25. PMID 37674364, Free PMC Article
    2. Molecular cloning of rat alpha1,3-fucosyltransferase IX (Fuc-TIX) and comparison of the expression of Fuc-TIV and Fuc-TIX genes during rat postnatal cerebellum development. Baboval T, et al. J Neurosci Res, 2000 Oct 15. PMID 11020213
    3. Expression of glycogenes in differentiating human NT2N neurons. Downregulation of fucosyltransferase 9 leads to decreased Lewis(x) levels and impaired neurite outgrowth. Gouveia R, et al. Biochim Biophys Acta, 2012 Dec. PMID 23000574
    4. Increased levels of fucosyltransferase IX and carbohydrate Lewis(x) adhesion determinant in human NT2N neurons. Brito C, et al. J Neurosci Res, 2007 May 1. PMID 17335083
    5. Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile. Toivonen S, et al. Glycobiology, 2002 Jun. PMID 12107078

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fucosyltransferase 9 promotes neuronal differentiation and functional recovery after spinal cord injury by suppressing the activation of Notch signaling.
      Title: Fucosyltransferase 9 promotes neuronal differentiation and functional recovery after spinal cord injury by suppressing the activation of Notch signaling.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fucosyltransferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Lewis x epitope biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Lewis x epitope biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in N-glycan fucosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fucosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fucosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycosphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosphingolipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nervous system development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuronal stem cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuronal stem cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polysaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polysaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of leukocyte cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of leukocyte tethering or rolling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
    Names
    alpha-(1,3)-fucosyltransferase 9
    fuc-TIX
    fucT-IX
    fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
    fucosyltransferase IX
    galactoside 3-L-fucosyltransferase
    NP_445917.1
    XP_038966805.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053465.2 → NP_445917.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

      See identical proteins and their annotated locations for NP_445917.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q99JB3
      UniProtKB/TrEMBL
      A6IIH6
      Related
      ENSRNOP00000100992.1, ENSRNOT00000155901.1
      Conserved Domains (2) summary
      pfam00852
      Location:185 → 354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62 → 169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      44148371..44361209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110877.2 → XP_038966805.1  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 isoform X1

      UniProtKB/Swiss-Prot
      Q99JB3
      UniProtKB/TrEMBL
      A6IIH6
      Related
      ENSRNOP00000087361.1, ENSRNOT00000113229.2
      Conserved Domains (2) summary
      pfam00852
      Location:185 → 354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:62 → 169
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JB3.1 GenPept UniProtKB/Swiss-Prot:Q99JB3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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