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    Ston1 stonin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360202, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ston1provided by RGD
    Official Full Name
    stonin 1provided by RGD
    Primary source
    RGD:727878
    See related
    EnsemblRapid:ENSRNOG00000016688 AllianceGenome:RGD:727878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Salf; Sblf
    Summary
    Predicted to enable clathrin adaptor activity. Predicted to be involved in clathrin-dependent endocytosis; regulation of endocytosis; and synaptic vesicle endocytosis. Predicted to act upstream of or within several processes, including cell-substrate junction organization; platelet-derived growth factor receptor signaling pathway; and ruffle assembly. Predicted to be located in cell leading edge; cell projection; and clathrin-coated pit. Predicted to be part of AP-2 adaptor complex. Predicted to be active in synaptic vesicle. Orthologous to several human genes including STON1 (stonin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 52.5), Uterus (RPKM 41.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ston1 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (11596726..11646098, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (5843186..5892557, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (12332465..12379783)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene luteinizing hormone/choriogonadotropin receptor Neighboring gene pyruvate kinase PKM-like Neighboring gene general transcription factor 2A subunit 1 like Neighboring gene uncharacterized LOC120103455 Neighboring gene uncharacterized LOC134479304 Neighboring gene ubiquitin-conjugating enzyme E2S, pseudogene 2 Neighboring gene protein phosphatase 1, regulatory subunit 21 Neighboring gene uncharacterized LOC102546644

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human stoned B interacts with AP-2 and synaptotagmin and facilitates clathrin-coated vesicle uncoating. Walther K, et al. EMBO Rep, 2001 Jul. PMID 11454741, Free PMC Article
    2. Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery. Martina JA, et al. J Cell Biol, 2001 May 28. PMID 11381094, Free PMC Article
    3. Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility. Feutlinske F, et al. Nat Commun, 2015 Oct 5. PMID 26437238, Free PMC Article
    4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cargo adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within focal adhesion disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within substrate-dependent cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    stonin-1
    Names
    stoned B-like factor
    stoned B/TFIIA-alpha/beta-like factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182954.2 → NP_891999.2  stonin-1

      See identical proteins and their annotated locations for NP_891999.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6H9B6, Q7TNJ9
      Related
      ENSRNOP00000088331.2, ENSRNOT00000118638.2
      Conserved Domains (1) summary
      cl10970
      Location:397 → 712
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      11596726..11646098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239743.4 → XP_006239805.1  stonin-1 isoform X1

      See identical proteins and their annotated locations for XP_006239805.1

      UniProtKB/TrEMBL
      A6H9B6, Q7TNJ9
      Conserved Domains (1) summary
      cl10970
      Location:397 → 712
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

    2. XM_039112436.1 → XP_038968364.1  stonin-1 isoform X2

      UniProtKB/TrEMBL
      F1MAC6, Q7TNJ9
      Conserved Domains (1) summary
      cl10970
      Location:379 → 694
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

    3. XM_063262036.1 → XP_063118106.1  stonin-1 isoform X1

      UniProtKB/TrEMBL
      A6H9B6, Q7TNJ9

    4. XM_008764481.3 → XP_008762703.1  stonin-1 isoform X1

      See identical proteins and their annotated locations for XP_008762703.1

      UniProtKB/TrEMBL
      A6H9B6, Q7TNJ9
      Conserved Domains (1) summary
      cl10970
      Location:397 → 712
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

    5. XM_006239744.5 → XP_006239806.1  stonin-1 isoform X1

      See identical proteins and their annotated locations for XP_006239806.1

      UniProtKB/TrEMBL
      A6H9B6, Q7TNJ9
      Conserved Domains (1) summary
      cl10970
      Location:397 → 712
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
    Nucleotide Protein Strain
    Heading Accession and Version

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