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    Rbm25 RNA binding motif protein 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbm25provided by RGD
    Official Full Name
    RNA binding motif protein 25provided by RGD
    Primary source
    RGD:1308755
    See related
    EnsemblRapid:ENSRNOG00000002874 AllianceGenome:RGD:1308755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome and regulation of apoptotic process. Predicted to be located in nuclear speck. Orthologous to human RBM25 (RNA binding motif protein 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 173.5), Spleen (RPKM 152.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbm25 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (108993119..109050159)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103271775..103319090)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107117888..107165538)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479227 Neighboring gene DDB1 and CUL4 associated factor 4 Neighboring gene uncharacterized LOC134479226 Neighboring gene zinc finger FYVE-type containing 1 Neighboring gene uncharacterized LOC102547293 Neighboring gene presenilin 1 Neighboring gene papilin, proteoglycan-like sulfated glycoprotein Neighboring gene NUMB, endocytic adaptor protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RBM25 binds to and regulates alternative splicing levels of Slc38a9, Csf1, and Coro6 to affect immune and inflammatory processes in H9c2 cells. Tian X, et al. PeerJ, 2023. PMID 37953772, Free PMC Article
    2. RBM25 regulates hypoxic cardiomyocyte apoptosis through CHOP-associated endoplasmic reticulum stress. Zhu Z, et al. Cell Stress Chaperones, 2023 Nov. PMID 37736860, Free PMC Article
    3. Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection. Zhou A, et al. Mol Cell Biol, 2008 Oct. PMID 18663000, Free PMC Article
    4. The sclerostin-bone protein interactome. Devarajan-Ketha H, et al. Biochem Biophys Res Commun, 2012 Jan 13. PMID 22206666, Free PMC Article
    5. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RBM25 regulates hypoxic cardiomyocyte apoptosis through CHOP-associated endoplasmic reticulum stress.
      Title: RBM25 regulates hypoxic cardiomyocyte apoptosis through CHOP-associated endoplasmic reticulum stress.
    2. RBM25 binds to and regulates alternative splicing levels of Slc38a9, Csf1, and Coro6 to affect immune and inflammatory processes in H9c2 cells.
      Title: RBM25 binds to and regulates alternative splicing levels of Slc38a9, Csf1, and Coro6 to affect immune and inflammatory processes in H9c2 cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395131.1 → NP_001382060.1  RNA-binding protein 25

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JDQ4, F1LT30
      Related
      ENSRNOP00000003834.8, ENSRNOT00000003834.9
      Conserved Domains (2) summary
      smart00311
      Location:756 → 829
      PWI; domain in splicing factors
      cd12446
      Location:87 → 169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      108993119..109050159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262229.1 → XP_063118299.1  RNA-binding protein 25 isoform X6

    2. XM_063262223.1 → XP_063118293.1  RNA-binding protein 25 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GMR5, F1LT30

    3. XM_063262225.1 → XP_063118295.1  RNA-binding protein 25 isoform X3

      UniProtKB/TrEMBL
      A6JDQ4, F1LT30

    4. XM_039112644.2 → XP_038968572.1  RNA-binding protein 25 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GMR5, F1LT30
      Related
      ENSRNOP00000097947.1, ENSRNOT00000113578.2
      Conserved Domains (2) summary
      smart00311
      Location:775 → 848
      PWI; domain in splicing factors
      cd12446
      Location:106 → 188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    5. XM_039112645.2 → XP_038968573.1  RNA-binding protein 25 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GMR5, F1LT30
      Conserved Domains (2) summary
      smart00311
      Location:775 → 848
      PWI; domain in splicing factors
      cd12446
      Location:106 → 188
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    6. XM_063262224.1 → XP_063118294.1  RNA-binding protein 25 isoform X2

      UniProtKB/TrEMBL
      F1LT30

    7. XM_039112647.2 → XP_038968575.1  RNA-binding protein 25 isoform X3

      UniProtKB/TrEMBL
      A6JDQ4, F1LT30
      Conserved Domains (2) summary
      smart00311
      Location:756 → 829
      PWI; domain in splicing factors
      cd12446
      Location:87 → 169
      RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

    8. XM_063262226.1 → XP_063118296.1  RNA-binding protein 25 isoform X4

      UniProtKB/TrEMBL
      F1LT30

    9. XM_063262227.1 → XP_063118297.1  RNA-binding protein 25 isoform X5

    10. XM_063262228.1 → XP_063118298.1  RNA-binding protein 25 isoform X5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108984.1: Suppressed sequence

      Description
      NM_001108984.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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