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    Kcns3 potassium voltage-gated channel, modifier subfamily S, member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83588, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcns3provided by RGD
    Official Full Name
    potassium voltage-gated channel, modifier subfamily S, member 3provided by RGD
    Primary source
    RGD:621527
    See related
    EnsemblRapid:ENSRNOG00000004899 AllianceGenome:RGD:621527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kv9.3
    Summary
    Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNS3 (potassium voltage-gated channel modifier subfamily S member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 121.7), Brain (RPKM 41.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcns3 in Genome Data Viewer
    Location:
    6q15
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (39527410..39584105, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (33808314..33865018, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (36764040..36819810, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103513 Neighboring gene presenilin associated, rhomboid-like, pseudogene 7 Neighboring gene uncharacterized LOC102547959 Neighboring gene mesogenin 1 Neighboring gene GEN1 Holliday junction 5' flap endonuclease

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Different Kv2.1/Kv9.3 heteromer expression during brain and lung post-natal development in the rat. Coma M, et al. J Physiol Biochem, 2002 Dec. PMID 12744302
    2. Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain. Stocker M, et al. Biochem Biophys Res Commun, 1998 Jul 30. PMID 9704029
    3. Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes. Patel AJ, et al. EMBO J, 1997 Nov 17. PMID 9362476, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    delayed-rectifier potassium channel regulatory subunit KCNS3; potassium voltage-gated channel subfamily S member 3
    Names
    Shab-related delayed-rectifier K+ channel (Kv9.3)
    delayed-rectifier K(+) channel alpha subunit 3
    delayed-rectifier potassium channel subunit Kv9.3
    potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
    voltage-gated potassium channel subunit Kv9.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389230.1 → NP_001376159.1  delayed-rectifier potassium channel regulatory subunit KCNS3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      O54900, O88759
      UniProtKB/TrEMBL
      A6HAP0
      Related
      ENSRNOP00000105842.1, ENSRNOT00000152198.1
      Conserved Domains (2) summary
      cd18428
      Location:15 → 122
      BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
      pfam00520
      Location:184 → 417
      Ion_trans; Ion transport protein

    2. NM_031778.3 → NP_113966.2  delayed-rectifier potassium channel regulatory subunit KCNS3

      See identical proteins and their annotated locations for NP_113966.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      O54900, O88759
      UniProtKB/TrEMBL
      A6HAP0
      Related
      ENSRNOP00000102174.1, ENSRNOT00000133371.1
      Conserved Domains (2) summary
      cd18428
      Location:15 → 122
      BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
      pfam00520
      Location:184 → 417
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      39527410..39584105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112998.2 → XP_038968926.1  potassium voltage-gated channel subfamily S member 3 isoform X1

      UniProtKB/Swiss-Prot
      O54900, O88759
      UniProtKB/TrEMBL
      A6HAP0
      Conserved Domains (2) summary
      cd18428
      Location:15 → 122
      BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
      pfam00520
      Location:184 → 417
      Ion_trans; Ion transport protein

    2. XM_039112997.2 → XP_038968925.1  potassium voltage-gated channel subfamily S member 3 isoform X1

      UniProtKB/Swiss-Prot
      O54900, O88759
      UniProtKB/TrEMBL
      A6HAP0
      Related
      ENSRNOP00000080054.1, ENSRNOT00000108088.2
      Conserved Domains (2) summary
      cd18428
      Location:15 → 122
      BTB_POZ_KCNS3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3)
      pfam00520
      Location:184 → 417
      Ion_trans; Ion transport protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88759.1 GenPept UniProtKB/Swiss-Prot:O88759

    Gene LinkOut

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