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    Zbtb25 zinc finger and BTB domain containing 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314245, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb25provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 25provided by RGD
    Primary source
    RGD:735076
    See related
    EnsemblRapid:ENSRNOG00000006441 AllianceGenome:RGD:735076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    KUP; Zfp50; Znf46
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZBTB25 (zinc finger and BTB domain containing 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 72.4), Adrenal (RPKM 51.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb25 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (100807083..100831555, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (95070699..95095888, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (99376415..99400834, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Neighboring gene A-kinase anchoring protein 5 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene uncharacterized LOC120103556 Neighboring gene heat shock protein family A (Hsp70) member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers. Chardin P, et al. Nucleic Acids Res, 1991 Apr 11. PMID 2027750, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 25
    Names
    zinc finger protein 46
    zinc finger protein 50

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433967.1 → NP_001420896.1  zinc finger and BTB domain-containing protein 25

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AB68, A6HCA4, F7F1F5, Q6P754

    2. NM_001433968.1 → NP_001420897.1  zinc finger and BTB domain-containing protein 25

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AB68, A6HCA4, F7F1F5, Q6P754

    3. NM_001433969.1 → NP_001420898.1  zinc finger and BTB domain-containing protein 25

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AB68, A6HCA4, F7F1F5, Q6P754

    4. NM_199496.2 → NP_955790.1  zinc finger and BTB domain-containing protein 25

      See identical proteins and their annotated locations for NP_955790.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AB68, A6HCA4, F7F1F5, Q6P754
      Related
      ENSRNOP00000008424.4, ENSRNOT00000008424.7
      Conserved Domains (3) summary
      sd00018
      Location:238 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18213
      Location:3 → 130
      BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
      pfam00096
      Location:240 → 260
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      100807083..100831555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240236.5 → XP_006240298.1  zinc finger and BTB domain-containing protein 25 isoform X1

      Conserved Domains (3) summary
      sd00018
      Location:238 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18213
      Location:3 → 130
      BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
      pfam00096
      Location:240 → 260
      zf-C2H2; Zinc finger, C2H2 type

    2. XM_006240237.5 → XP_006240299.1  zinc finger and BTB domain-containing protein 25 isoform X1

      Conserved Domains (3) summary
      sd00018
      Location:238 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18213
      Location:3 → 130
      BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
      pfam00096
      Location:240 → 260
      zf-C2H2; Zinc finger, C2H2 type

    3. XM_039112270.2 → XP_038968198.1  zinc finger and BTB domain-containing protein 25 isoform X1

      Conserved Domains (3) summary
      sd00018
      Location:238 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18213
      Location:3 → 130
      BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
      pfam00096
      Location:240 → 260
      zf-C2H2; Zinc finger, C2H2 type

    4. XM_039112269.2 → XP_038968197.1  zinc finger and BTB domain-containing protein 25 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AB68, A6HCA4, F7F1F5, Q6P754
      Conserved Domains (3) summary
      sd00018
      Location:238 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18213
      Location:3 → 130
      BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
      pfam00096
      Location:240 → 260
      zf-C2H2; Zinc finger, C2H2 type

    5. XM_039112271.2 → XP_038968199.1  zinc finger and BTB domain-containing protein 25 isoform X2

      Conserved Domains (2) summary
      sd00018
      Location:125 → 147
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:127 → 147
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein Strain
    Heading Accession and Version

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