Pnma1 PNMA family member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pnma1provided by RGD
Official Full Name: PNMA family member 1provided by RGD
Primary source: RGD:621230
See related: EnsemblRapid:ENSRNOG00000010553 AllianceGenome:RGD:621230
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MA1
Summary: Involved in inflammatory response to antigenic stimulus. Predicted to be located in cytoplasm and nucleolus. Orthologous to human PNMA1 (PNMA family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 6q31

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (109513382..109515167, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (103782244..103784029, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (107631227..107633012, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PNMA1 functions to promote neuronal death. PNMA1-mediated apoptosis can be prevented by Bcl2. Although the detailed mechanism remains to be delineated, it is likely to involve association of proteins with PNMA1 through its BH3-like sequence.
Title: Induction of neuronal cell death by paraneoplastic Ma1 antigen.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in inflammatory response to antigenic stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: paraneoplastic antigen Ma1 homolog

Names: paraneoplastic Ma antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.