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    Ptp4a3 protein tyrosine phosphatase 4A3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptp4a3provided by RGD
    Official Full Name
    protein tyrosine phosphatase 4A3provided by RGD
    Primary source
    RGD:1308687
    See related
    EnsemblRapid:ENSRNOG00000007628 AllianceGenome:RGD:1308687
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in several processes, including endothelial cell migration; positive regulation of establishment of protein localization; and positive regulation of non-canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of vascular permeability; and regulation of vascular endothelial growth factor signaling pathway. Predicted to be active in cytoplasm and nucleus. Orthologous to human PTP4A3 (protein tyrosine phosphatase 4A3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 596.4), Heart (RPKM 272.7) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptp4a3 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (107518220..107549949)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (105650640..105660921)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (114969699..115002902)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479924 Neighboring gene G protein-coupled receptor 20 Neighboring gene U4 spliceosomal RNA Neighboring gene maestro heat-like repeat family member 5 Neighboring gene ribosomal protein L29 like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo. Guo K, et al. Cancer Res, 2006 Oct 1. PMID 17018620
    2. Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility. Zimmerman MW, et al. J Biol Chem, 2014 Feb 28. PMID 24403062, Free PMC Article
    3. PRL-3 activates NF-κB signaling pathway by interacting with RAP1. Lian S, et al. Biochem Biophys Res Commun, 2013 Jan 4. PMID 23178297
    4. Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Fouillade C, et al. Arterioscler Thromb Vasc Biol, 2013 Jan. PMID 23117660, Free PMC Article
    5. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein tyrosine phosphatase type IVA 3
    Names
    protein tyrosine phosphatase type IVA, member 3
    NP_001107877.1
    XP_006241791.1
    XP_006241793.1
    XP_006241794.1
    XP_008763795.1
    XP_008763796.1
    XP_063119925.1
    XP_063119926.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114405.2 → NP_001107877.1  protein tyrosine phosphatase type IVA 3

      See identical proteins and their annotated locations for NP_001107877.1

      Status: PROVISIONAL

      Source sequence(s)
      BC159432
      UniProtKB/TrEMBL
      A0A8I5Y855, B0K032, F7EWD1
      Conserved Domains (1) summary
      cl28904
      Location:5 → 158
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      107518220..107549949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263855.1 → XP_063119925.1  protein tyrosine phosphatase type IVA 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y855, B0K032, F7EWD1

    2. XM_063263856.1 → XP_063119926.1  protein tyrosine phosphatase type IVA 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y855, B0K032, F7EWD1

    3. XM_008765573.4 → XP_008763795.1  protein tyrosine phosphatase type IVA 3 isoform X1

      See identical proteins and their annotated locations for XP_008763795.1

      UniProtKB/TrEMBL
      A0A8I5Y855, B0K032, F7EWD1
      Conserved Domains (1) summary
      cl28904
      Location:5 → 158
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. XM_006241731.5 → XP_006241793.1  protein tyrosine phosphatase type IVA 3 isoform X1

      See identical proteins and their annotated locations for XP_006241793.1

      UniProtKB/TrEMBL
      A0A8I5Y855, B0K032, F7EWD1
      Conserved Domains (1) summary
      cl28904
      Location:5 → 158
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    5. XM_008765574.4 → XP_008763796.1  protein tyrosine phosphatase type IVA 3 isoform X1

      See identical proteins and their annotated locations for XP_008763796.1

      UniProtKB/TrEMBL
      A0A8I5Y855, B0K032, F7EWD1
      Conserved Domains (1) summary
      cl28904
      Location:5 → 158
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    6. XM_006241729.5 → XP_006241791.1  protein tyrosine phosphatase type IVA 3 isoform X1

      See identical proteins and their annotated locations for XP_006241791.1

      UniProtKB/TrEMBL
      A0A8I5Y855, B0K032, F7EWD1
      Related
      ENSRNOP00000078100.1, ENSRNOT00000096141.2
      Conserved Domains (1) summary
      cl28904
      Location:5 → 158
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    7. XM_006241732.5 → XP_006241794.1  protein tyrosine phosphatase type IVA 3 isoform X1

      See identical proteins and their annotated locations for XP_006241794.1

      UniProtKB/TrEMBL
      A0A8I5Y855, B0K032, F7EWD1
      Conserved Domains (1) summary
      cl28904
      Location:5 → 158
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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