U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Maf1 MAF1 homolog, negative regulator of RNA polymerase III [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315093, updated on 9-Dec-2024

    Summary

    Official Symbol
    Maf1provided by RGD
    Official Full Name
    MAF1 homolog, negative regulator of RNA polymerase IIIprovided by RGD
    Primary source
    RGD:1359315
    See related
    EnsemblRapid:ENSRNOG00000013514 AllianceGenome:RGD:1359315
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GABA receptor binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase I and negative regulation of transcription by RNA polymerase III. Located in several cellular components, including dendrite; inhibitory synapse; and perinuclear region of cytoplasm. Orthologous to human MAF1 (MAF1 homolog, negative regulator of RNA polymerase III). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 570.0), Heart (RPKM 489.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Maf1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109955876..109958909)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108075173..108078252)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117417643..117420722)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cytochrome c-1 Neighboring gene SHANK-associated RH domain interactor Neighboring gene WD repeat domain 97 Neighboring gene HGH1 homolog

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in inhibitory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    repressor of RNA polymerase III transcription MAF1 homolog
    Names
    MAF1 negative regulator of RNA polymerase III

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014085.1NP_001014107.1  repressor of RNA polymerase III transcription MAF1 homolog

      See identical proteins and their annotated locations for NP_001014107.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083712
      UniProtKB/Swiss-Prot
      Q5XIH0
      UniProtKB/TrEMBL
      A6HS93
      Related
      ENSRNOP00000089214.2, ENSRNOT00000098036.2
      Conserved Domains (1) summary
      pfam09174
      Location:25202
      Maf1; Maf1 regulator

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      109955876..109958909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263594.1XP_063119664.1  repressor of RNA polymerase III transcription MAF1 homolog isoform X2

    2. XM_063263595.1XP_063119665.1  repressor of RNA polymerase III transcription MAF1 homolog isoform X5

    3. XM_006241811.3XP_006241873.1  repressor of RNA polymerase III transcription MAF1 homolog isoform X4

      Conserved Domains (1) summary
      pfam09174
      Location:17191
      Maf1; Maf1 regulator
    4. XM_063263596.1XP_063119666.1  repressor of RNA polymerase III transcription MAF1 homolog isoform X7

      Related
      ENSRNOP00000018240.7, ENSRNOT00000018240.7
    5. XM_063263593.1XP_063119663.1  repressor of RNA polymerase III transcription MAF1 homolog isoform X1

    6. XM_039079243.2XP_038935171.1  repressor of RNA polymerase III transcription MAF1 homolog isoform X3

      Conserved Domains (1) summary
      pfam09174
      Location:25202
      Maf1; Maf1 regulator
    7. XM_006241812.2XP_006241874.1  repressor of RNA polymerase III transcription MAF1 homolog isoform X6

      UniProtKB/TrEMBL
      A0A8L2Q923
      Conserved Domains (1) summary
      pfam09174
      Location:25202
      Maf1; Maf1 regulator