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    Slc25a3 solute carrier family 25 member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245959, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc25a3provided by RGD
    Official Full Name
    solute carrier family 25 member 3provided by RGD
    Primary source
    RGD:70986
    See related
    EnsemblRapid:ENSRNOG00000091320 AllianceGenome:RGD:70986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Phc
    Summary
    Predicted to enable phosphate transmembrane transporter activity and phosphate:proton symporter activity. Predicted to be involved in phosphate ion transmembrane transport. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human SLC25A3 (solute carrier family 25 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 8555.8), Muscle (RPKM 4996.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a3 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (27499164..27506685, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (25611937..25619401, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (31816601..31824064, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene apoptotic peptidase activating factor 1 Neighboring gene IKBKB interacting protein Neighboring gene small nucleolar RNA, H/ACA box 53 Neighboring gene cytochrome b-c1 complex subunit 7 pseudogene Neighboring gene thymopoietin Neighboring gene uncharacterized LOC134479859 Neighboring gene transfer RNA tryptophan (anticodon CCA) 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial phosphate transport. Import of the H+/Pi symporter and role of the presequence. Pratt RD, et al. J Biol Chem, 1991 Jan 15. PMID 1985946
    2. Mitochondrial proton/phosphate transporter. An antibody directed against the COOH terminus and proteolytic cleavage experiments provides new insights about its membrane topology. Ferreira GC, et al. J Biol Chem, 1990 Dec 5. PMID 2250020
    3. Role of mitochondrial phosphate carrier in metabolism-secretion coupling in rat insulinoma cell line INS-1. Nishi Y, et al. Biochem J, 2011 Apr 15. PMID 21265734
    4. Energy-linked anion transport. Cloning, sequencing, and characterization of a full length cDNA encoding the rat liver mitochondrial proton/phosphate symporter. Ferreira GC, et al. J Biol Chem, 1989 Sep 15. PMID 2670944
    5. Cytoprotective regulation of the mitochondrial permeability transition pore is impaired in type 2 diabetic Goto-Kakizaki rat hearts. Itoh T, et al. J Mol Cell Cardiol, 2012 Dec. PMID 23063677

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Pi supply to mitochondria via PiC plays a critical role in ATP production and metabolism-secretion coupling in INS-1 cells.
      Title: Role of mitochondrial phosphate carrier in metabolism-secretion coupling in rat insulinoma cell line INS-1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphate:proton symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphate:proton symporter activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial phosphate ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 25 member 3
    Names
    PTP
    adenine nucleotide translocator), member 3
    phosphate carrier protein, mitochondrial
    phosphate transport protein
    solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
    solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270788.1 → NP_001257717.1  solute carrier family 25 member 3 isoform 1

      See identical proteins and their annotated locations for NP_001257717.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC070918, CB577607
      UniProtKB/TrEMBL
      A0A0G2JYV5, A0A8I6GJ63, A6IFV2, Q6IRH6
      Related
      ENSRNOP00000070805.1, ENSRNOT00000080824.3
      Conserved Domains (2) summary
      PTZ00169
      Location:65 → 332
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:59 → 147
      Mito_carr; Mitochondrial carrier protein

    2. NM_139100.2 → NP_620800.2  solute carrier family 25 member 3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_620800.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate in-frame exon in place of an internal exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is slightly shorter and has internal aa differences compared to isoform 1.
      Source sequence(s)
      BC070918, CB577607
      UniProtKB/TrEMBL
      A0A8I6GJ63, A6IFV1, G3V741
      Conserved Domains (2) summary
      PTZ00169
      Location:65 → 331
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:58 → 146
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      27499164..27506685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262986.1 → XP_063119056.1  solute carrier family 25 member 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GJ63

    2. XM_063262985.1 → XP_063119055.1  solute carrier family 25 member 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJ63
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16036.1 GenPept UniProtKB/Swiss-Prot:P16036

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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