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    Nipal2 NIPA-like domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362899, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nipal2provided by RGD
    Official Full Name
    NIPA-like domain containing 2provided by RGD
    Primary source
    RGD:1564315
    See related
    EnsemblRapid:ENSRNOG00000005190 AllianceGenome:RGD:1564315
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Npal2; RGD1564315
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be active in membrane. Orthologous to human NIPAL2 (NIPA like domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 143.7), Heart (RPKM 82.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nipal2 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (67659628..67771105, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (65774477..65884807, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (73339706..73450262, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene POP1 homolog, ribonuclease P/MRP subunit Neighboring gene uncharacterized LOC120093631 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC134479710 Neighboring gene uncharacterized LOC134479602

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in magnesium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NIPA-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130559.1 → NP_001124031.1  NIPA-like protein 2

      See identical proteins and their annotated locations for NP_001124031.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A0A8I6AE26, A6HR07, D3ZKE2
      Related
      ENSRNOP00000006943.6, ENSRNOT00000006943.7
      Conserved Domains (1) summary
      pfam05653
      Location:45 → 331
      Mg_trans_NIPA; Magnesium transporter NIPA

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      67659628..67771105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263832.1 → XP_063119902.1  NIPA-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AE26, A6HR07, D3ZKE2

    2. XM_006241544.5 → XP_006241606.1  NIPA-like protein 2 isoform X2

      Conserved Domains (1) summary
      cl23754
      Location:45 → 256
      EamA; EamA-like transporter family

    3. XM_039079513.2 → XP_038935441.1  NIPA-like protein 2 isoform X3

      Conserved Domains (1) summary
      cl23754
      Location:8 → 149
      EamA; EamA-like transporter family
    Nucleotide Protein Strain
    Heading Accession and Version

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