Rrp7a ribosomal RNA processing 7 homolog A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rrp7aprovided by RGD
Official Full Name: ribosomal RNA processing 7 homolog Aprovided by RGD
Primary source: RGD:1311547
See related: EnsemblRapid:ENSRNOG00000022896 AllianceGenome:RGD:1311547
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cgi-96; RGD1311547
Summary: Predicted to enable nucleic acid binding activity. Predicted to be involved in cilium disassembly; protein localization to nucleolus; and ribosome biogenesis. Predicted to act upstream of or within blastocyst formation. Predicted to be located in several cellular components, including centrosome; cilium; and nucleolus. Predicted to be part of CURI complex; UTP-C complex; and small-subunit processome. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to several human genes including RRP7A (ribosomal RNA processing 7 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 99.7), Brain (RPKM 97.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (116142976..116152874, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (114262929..114272817, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (123980251..123990139, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst formation	ISO Inferred from Sequence Orthology more info
involved_in cilium disassembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleolus	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosome biogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CURI complex	IBA Inferred from Biological aspect of Ancestor more info
part_of UTP-C complex	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribosomal RNA-processing protein 7 homolog A

Names: gastric cancer antigen Zg14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130568.1 → NP_001124040.1 ribosomal RNA-processing protein 7 homolog A

See identical proteins and their annotated locations for NP_001124040.1

Status: PROVISIONAL

Source sequence(s)

CH473950

UniProtKB/TrEMBL

A0A8I6A4N9, A6HT82, D4AE65

Related

ENSRNOP00000033462.4, ENSRNOT00000034983.6

Conserved Domains (2) summary

cd12951
Location:151 → 280

RRP7_Rrp7A; RRP7 domain ribosomal RNA-processing protein 7 homolog A (Rrp7A) and similar proteins

cd12294
Location:59 → 159

RRM_Rrp7A; RNA recognition motif in ribosomal RNA-processing protein 7 homolog A (Rrp7A) and similar proteins