U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rabl2 RAB, member of RAS oncogene family like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362987, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rabl2provided by RGD
    Official Full Name
    RAB, member of RAS oncogene family like 2provided by RGD
    Primary source
    RGD:1306749
    See related
    EnsemblRapid:ENSRNOG00000013947 AllianceGenome:RGD:1306749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rabl2a; Rabl2b
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in intracellular protein transport; intraciliary transport; and photoreceptor cell morphogenesis. Predicted to act upstream of or within cilium assembly; flagellated sperm motility; and single fertilization. Predicted to be located in cytoplasm; microtubule organizing center; and sperm midpiece. Predicted to be part of intraciliary transport particle B. Predicted to be active in endomembrane system. Orthologous to several human genes including RABL2B (RAB, member of RAS oncogene family like 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 83.3), Brain (RPKM 49.0) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rabl2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122531787..122540500, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120652175..120660906, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130556056..130564764, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene SH3 and multiple ankyrin repeat domains 3 Neighboring gene uncharacterized LOC108351527 Neighboring gene septin 7, pseudogene 3 Neighboring gene acrosin Neighboring gene ribosomal protein L9, pseudogene 2 Neighboring gene uncharacterized LOC120093828

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly. Nishijima Y, et al. Mol Biol Cell, 2017 Jun 15. PMID 28428259, Free PMC Article
    2. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Kanie T, et al. Dev Cell, 2017 Jul 10. PMID 28625565, Free PMC Article
    3. RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Lo JC, et al. PLoS Genet, 2012. PMID 23055941, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in photoreceptor cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    rab-like protein 2B
    Names
    RAB, member of RAS oncogene family-like 2A
    RAB, member of RAS oncogene family-like 2B
    rab-like protein 2A

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013221.1 → NP_001013239.1  rab-like protein 2B

      See identical proteins and their annotated locations for NP_001013239.1

      Status: VALIDATED

      Source sequence(s)
      BC083624
      UniProtKB/TrEMBL
      A6K7P0, F1M7Q2, Q5XIQ1
      Conserved Domains (2) summary
      cd04124
      Location:22 → 181
      RabL2; Rab GTPase-like family 2 (Rab-like2)
      smart00175
      Location:22 → 170
      RAB; Rab subfamily of small GTPases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      122531787..122540500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242227.4 → XP_006242289.1  rab-like protein 2B isoform X2

      See identical proteins and their annotated locations for XP_006242289.1

      UniProtKB/TrEMBL
      A6K7P0
      Conserved Domains (1) summary
      cd04124
      Location:22 → 182
      RabL2; Rab GTPase-like family 2 (Rab-like2)

    2. XM_006242225.5 → XP_006242287.1  rab-like protein 2B isoform X1

      UniProtKB/TrEMBL
      A0A0G2QC52
      Related
      ENSRNOP00000040188.5, ENSRNOT00000044262.7
      Conserved Domains (2) summary
      cd04124
      Location:49 → 209
      RabL2; Rab GTPase-like family 2 (Rab-like2)
      smart00175
      Location:49 → 198
      RAB; Rab subfamily of small GTPases

    3. XM_063263949.1 → XP_063120019.1  rab-like protein 2B isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools