Krt87 keratin 87 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Krt87provided by RGD
Official Full Name: keratin 87provided by RGD
Primary source: RGD:1583565
See related: EnsemblRapid:ENSRNOG00000032859 AllianceGenome:RGD:1583565
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Krt83
Summary: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in hair cycle; intermediate filament organization; and keratinization. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 5 and monilethrix. Orthologous to human KRT83 (keratin 83). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 24.6) and Uterus (RPKM 5.7) See more
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Genomic context

Location:: 7q36

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (134426567..134433740, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (132547388..132555005, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (143078996..143085833, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in hair cycle	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: keratin, type II cuticular Hb3

Names: keratin 83; keratin 83, type II; keratin complex 2, basic, gene 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001101675.2 → NP_001095145.1 keratin, type II cuticular Hb3

See identical proteins and their annotated locations for NP_001095145.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6A9T4, A7M746, D4ABK6

Related

ENSRNOP00000029805.3, ENSRNOT00000031257.6

Conserved Domains (3) summary

pfam00038
Location:110 → 421

Filament; Intermediate filament protein

pfam16208
Location:4 → 107

Keratin_2_head; Keratin type II head

cl23720
Location:320 → 388

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)