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    Sp7 Sp7 transcription factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300260, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sp7provided by RGD
    Official Full Name
    Sp7 transcription factorprovided by RGD
    Primary source
    RGD:631377
    See related
    EnsemblRapid:ENSRNOG00000014082 AllianceGenome:RGD:631377
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Osx
    Summary
    Predicted to enable DEAD/H-box RNA helicase binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to zinc ion starvation; response to insulin; and response to organic cyclic compound. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 12. Orthologous to human SP7 (Sp7 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 5.1), Uterus (RPKM 0.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sp7 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135363193..135373376, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133484609..133494788, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143957316..143967488, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene MYG1 exonuclease Neighboring gene aladin WD repeat nucleoporin Neighboring gene Sp1 transcription factor Neighboring gene uncharacterized LOC134479584 Neighboring gene anti-Mullerian hormone receptor type 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Osterix overexpression enhances osteoblast differentiation of muscle satellite cells in vitro. Sun S, et al. Int J Oral Maxillofac Surg, 2008 Apr. PMID 18272339
    2. Localization of SUMOylation factors and Osterix in odontoblast lineage cells during dentin formation and regeneration. Hosoya A, et al. Histochem Cell Biol, 2013 Aug. PMID 23354182
    3. Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells. Milona MA, et al. BMC Genomics, 2003 Nov 7. PMID 14604442, Free PMC Article
    4. Expression of RUNX2 and Osterix in Rat Mesenchymal Stem Cells during Culturing in Osteogenic-Conditioned Medium. Pokrovskaya LA, et al. Bull Exp Biol Med, 2020 Aug. PMID 32910396
    5. Parathyroid hormone regulates osterix and Runx2 mRNA expression predominantly through protein kinase A signaling in osteoblast-like cells. Wang BL, et al. J Endocrinol Invest, 2006 Feb. PMID 16610234

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spatio-temporal immunolocalization of VEGF-A, Runx2, and osterix during the early steps of intramembranous ossification of the alveolar process in rat embryos.
      Title: Spatio-temporal immunolocalization of VEGF-A, Runx2, and osterix during the early steps of intramembranous ossification of the alveolar process in rat embryos.
    2. Expression of RUNX2 and Osterix in Rat Mesenchymal Stem Cells during Culturing in Osteogenic-Conditioned Medium.
      Title: Expression of RUNX2 and Osterix in Rat Mesenchymal Stem Cells during Culturing in Osteogenic-Conditioned Medium.
    3. BMP2-mimicking peptide modified with E7 coupling to calcined bovine bone enhanced bone regeneration associating with activation of the Runx2/SP7 signaling axis.
      Title: BMP2-mimicking peptide modified with E7 coupling to calcined bovine bone enhanced bone regeneration associating with activation of the Runx2/SP7 signaling axis.
    4. Lysine-Specific Demethylase 4A Regulates Osteogenic Differentiation via Regulating the Binding Ability of H3K9me3 with the Promoters of Runx2, Osterix and Osteocalcin.
      Title: Lysine-Specific Demethylase 4A Regulates Osteogenic Differentiation via Regulating the Binding Ability of H3K9me3 with the Promoters of Runx2, Osterix and Osteocalcin.
    5. the results indicate that, Osx-overexpression promotes ADSCs' osteogenesis both in vitro and in vivo, which could be enhanced by release of VEGF.
      Title: In Situ Release of VEGF Enhances Osteogenesis in 3D Porous Scaffolds Engineered with Osterix-Modified Adipose-Derived Stem Cells.
    6. In orthodontic tooth movement, the expression of RUNX2 and OSX was upregulated as a result of external stimulation, suggesting that the two genes is involved in periodontal tissue remodeling and plays an important role in periodontal tissue remodeling.
      Title: Expression and function of osteogenic genes runt-related transcription factor 2 and osterix in orthodontic tooth movement in rats.
    7. positive expression for Osterix and HNK1 in undifferentiated ectomesenchymal cells in early and late stages; Sox10 was present only in early stages in undifferentiated cells
      Title: Temporo-spatial analysis of Osterix, HNK1 and Sox10 during odontogenesis and maxillaries osteogenesis.
    8. VDR may mediate the increased expression levels of BMP2, Runx2 and Osterix by positively regulating calcium levels in primary primary renal tubular epithelial cells.
      Title: Role of calcium in the regulation of bone morphogenetic protein 2, runt-related transcription factor 2 and Osterix in primary renal tubular epithelial cells by the vitamin D receptor.
    9. results suggest that SUMOylation might regulate the transcriptional activity of Osterix in odontoblast lineage cells, and thus play important roles in odontoblast differentiation and regeneration
      Title: Localization of SUMOylation factors and Osterix in odontoblast lineage cells during dentin formation and regeneration.
    10. Glucocorticoids may induce femoral head osteonecrosis by down-regulating Runx2/Osterix (Osx) mRNA and up-regulating AJ18 mRNA.
      Title: Dynamic expression of Runx2, Osterix and AJ18 in the femoral head of steroid-induced osteonecrosis in rats.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DEAD/H-box RNA helicase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to zinc ion starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cementum mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in diphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hematopoietic stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to insulin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor Sp7
    Names
    osterix

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037632.1 → NP_001032721.1  transcription factor Sp7 isoform 1

      See identical proteins and their annotated locations for NP_001032721.1

      Status: PROVISIONAL

      Source sequence(s)
      BK001413
      UniProtKB/TrEMBL
      Q6IMK1, Q811U1
      Related
      ENSRNOP00000074457.1, ENSRNOT00000081758.3
      Conserved Domains (3) summary
      COG5048
      Location:288 → 355
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:278 → 297
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:319 → 344
      zf-H2C2_2; Zinc-finger double domain

    2. NM_181374.2 → NP_852039.2  transcription factor Sp7 isoform 2

      See identical proteins and their annotated locations for NP_852039.2

      Status: PROVISIONAL

      Source sequence(s)
      BK001412
      UniProtKB/TrEMBL
      F7EYG4, Q6IMK2, Q811U1
      Conserved Domains (3) summary
      COG5048
      Location:306 → 373
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:296 → 315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:337 → 362
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      135363193..135373376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594791.3 → XP_017450280.1  transcription factor Sp7 isoform X1

      UniProtKB/TrEMBL
      F7EYG4, Q6IMK2, Q811U1
      Conserved Domains (3) summary
      COG5048
      Location:306 → 373
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:296 → 315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:337 → 362
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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