Esam endothelial cell adhesion molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Esamprovided by RGD
Official Full Name: endothelial cell adhesion moleculeprovided by RGD
Primary source: RGD:1303286
See related: EnsemblRapid:ENSRNOG00000033217 AllianceGenome:RGD:1303286
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in several processes, including bicellular tight junction assembly; homophilic cell adhesion via plasma membrane adhesion molecules; and regulation of actin filament polymerization. Predicted to act upstream of or within cell-cell adhesion. Predicted to be located in bicellular tight junction. Predicted to be part of protein-containing complex. Predicted to be active in adherens junction and plasma membrane. Orthologous to human ESAM (endothelial cell adhesion molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 460.5), Heart (RPKM 196.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (45426985..45437976)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (37238228..37249217)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (39997875..40008802)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cell-cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endothelial cell-selective adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004245.1 → NP_001004245.1 endothelial cell-selective adhesion molecule precursor

See identical proteins and their annotated locations for NP_001004245.1

Status: PROVISIONAL

Source sequence(s)

BC079093

UniProtKB/Swiss-Prot

Q6AYD4

UniProtKB/TrEMBL

A6KRK8

Related

ENSRNOP00000051485.2, ENSRNOT00000050609.6

Conserved Domains (3) summary

smart00408
Location:170 → 234

IGc2; Immunoglobulin C-2 Type

smart00410
Location:169 → 244

IG_like; Immunoglobulin like

pfam07686
Location:42 → 153

V-set; Immunoglobulin V-set domain