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    Calml4 calmodulin-like 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Calml4provided by RGD
    Official Full Name
    calmodulin-like 4provided by RGD
    Primary source
    RGD:1583918
    See related
    AllianceGenome:RGD:1583918
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity; enzyme regulator activity; and myosin head/neck binding activity. Predicted to be involved in brush border assembly and microtubule cytoskeleton organization. Predicted to be located in microvillus. Predicted to be active in cytoplasm. Orthologous to human CALML4 (calmodulin like 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 860.8), Spleen (RPKM 98.5) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Calml4 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (72218870..72230650)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (63323426..63335234)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (67753279..67765359)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene fem-1 homolog B Neighboring gene uncharacterized LOC102546547 Neighboring gene CLN6, transmembrane ER protein Neighboring gene protein inhibitor of activated STAT, 1 Neighboring gene uncharacterized LOC134480067 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin head/neck binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in brush border assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin-like protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127575.1 → NP_001121047.1  calmodulin-like protein 4

      See identical proteins and their annotated locations for NP_001121047.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473975
      UniProtKB/TrEMBL
      B0BNB8
      Conserved Domains (3) summary
      PTZ00184
      Location:1 → 144
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:12 → 74
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl08302
      Location:94 → 147
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      72218870..72230650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243243.4 → XP_006243305.1  calmodulin-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZX47, A6J589
      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 108
      PTZ00184; calmodulin; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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