Jam3 junctional adhesion molecule 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Jam3provided by RGD
Official Full Name: junctional adhesion molecule 3provided by RGD
Primary source: RGD:1303248
See related: EnsemblRapid:ENSRNOG00000009149 AllianceGenome:RGD:1303248
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cell-cell adhesion mediator activity; identical protein binding activity; and integrin binding activity. Involved in axon regeneration. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; bicellular tight junction; and paranodal junction. Predicted to be part of filamentous actin and protein complex involved in cell adhesion. Predicted to be active in cell-cell contact zone and plasma membrane. Biomarker of sciatic neuropathy. Orthologous to human JAM3 (junctional adhesion molecule 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 114.4), Brain (RPKM 78.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (33767606..33828451, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (25508461..25569306, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (28147110..28208466, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cell-cell adhesion mediator activity	IEA Inferred from Electronic Annotation more info
enables cell-cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in adherens junction assembly	IEA Inferred from Electronic Annotation more info
involved_in adherens junction assembly	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in apical protein localization	IEA Inferred from Electronic Annotation more info
involved_in apical protein localization	ISO Inferred from Sequence Orthology more info
involved_in axon regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in granulocyte migration	IEA Inferred from Electronic Annotation more info
involved_in granulocyte migration	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic stem cell migration to bone marrow	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic stem cell migration to bone marrow	ISO Inferred from Sequence Orthology more info
involved_in heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte migration involved in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of integrin activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of integrin activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane permeability	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of membrane permeability	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte extravasation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of monocyte extravasation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell junction	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cell junction	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of actin cytoskeleton organization by cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatid development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transmission of nerve impulse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Schmidt-Lanterman incisure	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell-cell contact zone	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell contact zone	IEA Inferred from Electronic Annotation more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in desmosome	IEA Inferred from Electronic Annotation more info
located_in desmosome	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	IEA Inferred from Electronic Annotation more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in paranodal junction	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein complex involved in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
part_of protein complex involved in cell adhesion	IEA Inferred from Electronic Annotation more info
part_of protein complex involved in cell adhesion	ISO Inferred from Sequence Orthology more info
part_of protein complex involved in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: junctional adhesion molecule C

Names: JAM-3; JAM-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004269.1 → NP_001004269.1 junctional adhesion molecule C precursor

See identical proteins and their annotated locations for NP_001004269.1

Status: PROVISIONAL

Source sequence(s)

BC079429

UniProtKB/Swiss-Prot

Q68FQ2

UniProtKB/TrEMBL

A0A8I6ANI6, A6JYE0

Related

ENSRNOP00000012247.4, ENSRNOT00000012247.6

Conserved Domains (3) summary

cd00096
Location:156 → 231

Ig; Immunoglobulin domain

pfam07679
Location:39 → 135

I-set; Immunoglobulin I-set domain

cl11960
Location:37 → 118

Ig; Immunoglobulin domain