Fam83b family with sequence similarity 83, member B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fam83bprovided by RGD
Official Full Name: family with sequence similarity 83, member Bprovided by RGD
Primary source: RGD:1311988
See related: EnsemblRapid:ENSRNOG00000069372 AllianceGenome:RGD:1311988
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311988
Summary: Predicted to enable epidermal growth factor receptor binding activity; phosphatidylinositol 3-kinase binding activity; and protein kinase binding activity. Predicted to be involved in cell population proliferation; positive regulation of epidermal growth factor receptor signaling pathway; and signal transduction. Predicted to be active in cytoplasm and membrane. Orthologous to human FAM83B (family with sequence similarity 83 member B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 14.3), Adrenal (RPKM 13.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (86167778..86244222, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (77287351..77363795, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (83616148..83693484, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D8Rat23 (e-PCR)
- UniSTS:119091

AI176334 (e-PCR)
- UniSTS:250194

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase catalytic subunit binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase regulatory subunit binding	ISO Inferred from Sequence Orthology more info
NOT enables phospholipase D activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein FAM83B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108169.1 → NP_001101639.1 protein FAM83B

See identical proteins and their annotated locations for NP_001101639.1

Status: PROVISIONAL

Source sequence(s)

CH473954

UniProtKB/TrEMBL

A6I1F6, D3ZF70

Related

ENSRNOP00000085549.1, ENSRNOT00000117584.2

Conserved Domains (3) summary

cd09182
Location:17 → 283

PLDc_FAM83B_N; N-terminal phospholipase D-like domain of the uncharacterized protein, Family with sequence similarity 83B

pfam11489
Location:496 → 832

DUF3210; Protein of unknown function (DUF3210)

pfam13091
Location:139 → 276

PLDc_2; PLD-like domain