Nck1 NCK adaptor protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nck1provided by RGD
Official Full Name: NCK adaptor protein 1provided by RGD
Primary source: RGD:1310688
See related: EnsemblRapid:ENSRNOG00000014917 AllianceGenome:RGD:1310688
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including eukaryotic initiation factor eIF2 binding activity; molecular condensate scaffold activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antiviral innate immune response; regulation of gene expression; and regulation of response to endoplasmic reticulum stress. Predicted to act upstream of or within several processes, including actin filament organization; plasma membrane bounded cell projection assembly; and positive regulation of cellular component organization. Predicted to be located in several cellular components, including cell-cell junction; endoplasmic reticulum; and ribosome. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in cytoplasm. Orthologous to human NCK1 (NCK adaptor protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 232.0), Spleen (RPKM 222.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (109897723..109958247, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (101018610..101079237, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (108787797..108847779, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nck is required to maintain adult podocytes and phosphotyrosine-based interactions with nephrin may occur in foot processes of resting, mature podocytes.
Title: Nck proteins maintain the adult glomerular filtration barrier.
Modulation of protein translation by Nck-1.
Title: Modulation of protein translation by Nck-1.
Nck couples nephrin to the actin cytoskeleton in glomerular podocytes and contributes to the maintenance of normal morphology and function of podocytes
Title: Rat nephrin modulates cell morphology via the adaptor protein Nck.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ephrin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic initiation factor eIF2 binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein sequestering activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of PERK-mediated unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of PERK-mediated unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cap-dependent translational initiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cap-independent translational initiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation in response to endoplasmic reticulum stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translation in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to other organism	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within substrate-dependent cell migration, cell extension	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein phosphatase type 1 complex	ISO Inferred from Sequence Orthology more info
located_in ribosome	ISO Inferred from Sequence Orthology more info
located_in vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SH2/SH3 adapter protein NCK1

Names: cytoplasmic protein NCK1; non-catalytic region of tyrosine kinase adaptor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106851.2 → NP_001100321.1 SH2/SH3 adapter protein NCK1

See identical proteins and their annotated locations for NP_001100321.1

Status: PROVISIONAL

Source sequence(s)

BC167009

UniProtKB/TrEMBL

A0A9K3Y859, B2RZ33, G3V7X3

Related

ENSRNOP00000020330.7, ENSRNOT00000020330.9

Conserved Domains (4) summary

cd10408
Location:280 → 376

SH2_Nck1; Src homology 2 (SH2) domain found in Nck

cd11900
Location:3 → 61

SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein

cd11901
Location:108 → 162

SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein

cd11904
Location:193 → 249

SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

109897723..109958247 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081189.2 → XP_038937117.1 SH2/SH3 adapter protein NCK1 isoform X1

UniProtKB/TrEMBL

A0A9K3Y859, B2RZ33, G3V7X3

Conserved Domains (4) summary

cd10408
Location:280 → 376

SH2_Nck1; Src homology 2 (SH2) domain found in Nck

cd11900
Location:3 → 61

SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein

cd11901
Location:108 → 162

SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein

cd11904
Location:193 → 249

SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
XM_063265226.1 → XP_063121296.1 SH2/SH3 adapter protein NCK1 isoform X1

UniProtKB/TrEMBL

A0A9K3Y859, B2RZ33, G3V7X3
XM_063265225.1 → XP_063121295.1 SH2/SH3 adapter protein NCK1 isoform X1

UniProtKB/TrEMBL

A0A9K3Y859, B2RZ33, G3V7X3
XM_039081190.2 → XP_038937118.1 SH2/SH3 adapter protein NCK1 isoform X2

UniProtKB/TrEMBL

A0A0G2JUA7, A6I2F5

Related

ENSRNOP00000069028.2, ENSRNOT00000091593.3

Conserved Domains (3) summary

cd10408
Location:216 → 312

SH2_Nck1; Src homology 2 (SH2) domain found in Nck

cd11901
Location:44 → 98

SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein

cd11904
Location:129 → 185

SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein