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    Lipt1 lipoyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316342, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lipt1provided by RGD
    Official Full Name
    lipoyltransferase 1provided by RGD
    Primary source
    RGD:1310276
    See related
    EnsemblRapid:ENSRNOG00000018464 AllianceGenome:RGD:1310276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable lipoyltransferase activity. Predicted to be involved in protein lipoylation. Predicted to be active in mitochondrion. Orthologous to human LIPT1 (lipoyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 18.9), Kidney (RPKM 14.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lipt1 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (47603972..47609365)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (40107938..40118268)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (44466627..44471986)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene testis specific 10 Neighboring gene chromosome 9 C2orf15 homolog Neighboring gene microtubule interacting and trafficking domain containing 1 Neighboring gene mitochondrial ribosomal protein L30

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipoyl amidotransferase LIPT1, mitochondrial
    Names
    lipoyltransferase 1, mitochondrial
    NP_001101682.1
    XP_006244877.1
    XP_006244879.1
    XP_006244880.1
    XP_063123227.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108212.2 → NP_001101682.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001101682.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6INI4, D3Z7Z4
      Related
      ENSRNOP00000112399.1, ENSRNOT00000153120.1
      Conserved Domains (1) summary
      cd16443
      Location:33 → 235
      LplA; lipoate-protein ligase

    2. NM_001432402.1 → NP_001419331.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6INI4, D3Z7Z4

    3. NM_001432403.1 → NP_001419332.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6INI4, D3Z7Z4

    4. NM_001432404.1 → NP_001419333.1  lipoyl amidotransferase LIPT1, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6INI4, D3Z7Z4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      47603972..47609365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244818.4 → XP_006244880.1  lipoyl amidotransferase LIPT1, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd16443
      Location:33 → 235
      LplA; lipoate-protein ligase

    2. XM_063267157.1 → XP_063123227.1  lipoyl amidotransferase LIPT1, mitochondrial isoform X2

    3. XM_006244815.4 → XP_006244877.1  lipoyl amidotransferase LIPT1, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRJ8
      Related
      ENSRNOP00000080751.1, ENSRNOT00000098250.2
      Conserved Domains (1) summary
      COG0095
      Location:67 → 310
      LplA; Lipoate-protein ligase A [Coenzyme transport and metabolism]

    4. XM_006244817.4 → XP_006244879.1  lipoyl amidotransferase LIPT1, mitochondrial isoform X3

      Related
      ENSRNOP00000110622.1, ENSRNOT00000128349.1
      Conserved Domains (1) summary
      cd16443
      Location:33 → 235
      LplA; lipoate-protein ligase
    Nucleotide Protein Strain
    Heading Accession and Version

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