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    Pms1 PMS1 homolog 1, mismatch repair system component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 494322, updated on 9-Dec-2024

    Summary

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    Symbol
    Pms1provided by RGD
    Full Name
    PMS1 homolog 1, mismatch repair system componentprovided by RGD
    Primary source
    RGD:1359511
    See related
    EnsemblRapid:ENSRNOG00000004076 AllianceGenome:RGD:1359511
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP hydrolysis activity and enzyme binding activity. Involved in response to xenobiotic stimulus. Predicted to be located in nucleus. Predicted to be part of MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome; dermatomyositis; pancreatic ductal carcinoma; and polymyositis. Orthologous to human PMS1 (PMS1 homolog 1, mismatch repair system component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 79.5), Thymus (RPKM 70.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pms1 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (55721393..55832225)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (48229403..48340237)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (53120656..53206520)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 40 member 1 Neighboring gene ASNSD1 upstream open reading frame Neighboring gene asparagine synthetase domain containing 1 Neighboring gene ankyrin and armadillo repeat containing Neighboring gene O-sialoglycoprotein endopeptidase-like 1 Neighboring gene ORMDL sphingolipid biosynthesis regulator 1 Neighboring gene large ribosomal subunit protein eL37-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene myostatin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis. Okada T, et al. Int J Cancer, 2005 Oct 10. PMID 15856462
    2. Expression of base excision, mismatch, and recombination repair genes in the organogenesis-stage rat conceptus and effects of exposure to a genotoxic teratogen, 4-hydroperoxycyclophosphamide. Vinson RK, et al. Teratology, 2001 Dec. PMID 11754170
    3. DNA mismatch repair defects: role in colorectal carcinogenesis. Jacob S, et al. Biochimie, 2002 Jan. PMID 11900875
    4. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nicolaides NC, et al. Nature, 1994 Sep 1. PMID 8072530
    5. Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Prolla TA, et al. Nat Genet, 1998 Mar. PMID 9500552

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC72584

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mismatch repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MutLalpha complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    PMS1 protein homolog 1
    Names
    PMS1 postmeiotic segregation increased 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009535.1 → NP_001009535.1  PMS1 protein homolog 1

      See identical proteins and their annotated locations for NP_001009535.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061722
      UniProtKB/TrEMBL
      A0A8I6AGZ9, Q6P7D0
      Related
      ENSRNOP00000109326.1, ENSRNOT00000173627.1
      Conserved Domains (4) summary
      cd01390
      Location:561 → 625
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      cd03485
      Location:205 → 338
      MutL_Trans_hPMS_1_like; MutL_Trans_hPMS1_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM1 (hPSM1) and yeast MLH2. hPSM1 and yMLH2 are members of the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is ...
      TIGR00585
      Location:1 → 318
      mutl; DNA mismatch repair protein MutL
      pfam02518
      Location:18 → 102
      HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      55721393..55832225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084041.1 → XP_038939969.1  PMS1 protein homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AGZ9, D4A651
      Conserved Domains (2) summary
      cd01390
      Location:561 → 625
      HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
      TIGR00585
      Location:1 → 318
      mutl; DNA mismatch repair protein MutL

    2. XM_039084044.2 → XP_038939972.1  PMS1 protein homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AGZ9, D4A651
      Conserved Domains (2) summary
      cd01390
      Location:561 → 625
      HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
      TIGR00585
      Location:1 → 318
      mutl; DNA mismatch repair protein MutL

    3. XM_039084043.2 → XP_038939971.1  PMS1 protein homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AGZ9, D4A651
      Related
      ENSRNOP00000047584.4, ENSRNOT00000043714.6
      Conserved Domains (2) summary
      cd01390
      Location:561 → 625
      HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
      TIGR00585
      Location:1 → 318
      mutl; DNA mismatch repair protein MutL

    4. XM_039084042.2 → XP_038939970.1  PMS1 protein homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AGZ9, D4A651
      Conserved Domains (2) summary
      cd01390
      Location:561 → 625
      HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
      TIGR00585
      Location:1 → 318
      mutl; DNA mismatch repair protein MutL

    5. XM_039084045.2 → XP_038939973.1  PMS1 protein homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AGZ9, D4A651
      Conserved Domains (2) summary
      cd01390
      Location:561 → 625
      HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
      TIGR00585
      Location:1 → 318
      mutl; DNA mismatch repair protein MutL

    6. XM_039084046.1 → XP_038939974.1  PMS1 protein homolog 1 isoform X2

      UniProtKB/TrEMBL
      A6INU7
      Conserved Domains (2) summary
      cd01390
      Location:354 → 418
      HMGB-UBF_HMG-box; class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal ...
      cd03485
      Location:1 → 131
      MutL_Trans_hPMS_1_like; MutL_Trans_hPMS1_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM1 (hPSM1) and yeast MLH2. hPSM1 and yMLH2 are members of the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is ...

    RNA

    1. XR_010054623.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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