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    Mfsd6 major facilitator superfamily domain containing 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301388, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mfsd6provided by RGD
    Official Full Name
    major facilitator superfamily domain containing 6provided by RGD
    Primary source
    RGD:1562317
    See related
    EnsemblRapid:ENSRNOG00000012663 AllianceGenome:RGD:1562317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562317
    Summary
    Predicted to enable MHC class I protein binding activity and MHC class I receptor activity. Predicted to be involved in antigen processing and presentation of exogenous peptide antigen via MHC class I. Predicted to be active in plasma membrane. Orthologous to human MFSD6 (major facilitator superfamily domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 75.0), Liver (RPKM 54.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mfsd6 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (56265152..56350449)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (48773171..48858471)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (53626412..53710820)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene post-GPI attachment to proteins 2, pseudogene 2 Neighboring gene BCL2 interacting protein 3, pseudogene 1 Neighboring gene nuclear envelope integral membrane protein 2 Neighboring gene developmental pluripotency-associated protein 3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Macrophage MHC receptor 2: a novel receptor on allograft (H-2D(d)K(d))-induced macrophage (H-2D(b)K(b)) recognizing an MHC class I molecule, H-2K(d), in mice. Tashiro-Yamaji J, et al. Gene, 2006 Dec 15. PMID 17010536
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MHC class I receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    major facilitator superfamily domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106911.2 → NP_001100381.1  major facilitator superfamily domain-containing protein 6 isoform 1

      See identical proteins and their annotated locations for NP_001100381.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2JW92, A6INV8, D3ZCJ3
      Related
      ENSRNOP00000036787.4, ENSRNOT00000031267.8
      Conserved Domains (4) summary
      cd06174
      Location:453 → 623
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:453 → 651
      MFS_1; Major Facilitator Superfamily
      pfam12832
      Location:68 → 143
      MFS_1_like; MFS_1 like family
      pfam16038
      Location:366 → 395
      TMIE; TMIE protein

    2. NM_001432455.1 → NP_001419384.1  major facilitator superfamily domain-containing protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2JW92, A6INV8, D3ZCJ3

    3. NM_001432456.1 → NP_001419385.1  major facilitator superfamily domain-containing protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2JW92, A0A8I6ALE1

    4. NM_001432457.1 → NP_001419386.1  major facilitator superfamily domain-containing protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2JW92, A0A8I6ALE1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      56265152..56350449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244898.5 → XP_006244960.1  major facilitator superfamily domain-containing protein 6 isoform X2

      Conserved Domains (4) summary
      cd06174
      Location:453 → 623
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:453 → 651
      MFS_1; Major Facilitator Superfamily
      pfam12832
      Location:68 → 143
      MFS_1_like; MFS_1 like family
      pfam16038
      Location:366 → 395
      TMIE; TMIE protein

    2. XM_063266940.1 → XP_063123010.1  major facilitator superfamily domain-containing protein 6 isoform X2

      Related
      ENSRNOP00000094609.1, ENSRNOT00000104195.2

    3. XM_017596349.3 → XP_017451838.1  major facilitator superfamily domain-containing protein 6 isoform X1

      Related
      ENSRNOP00000069791.2, ENSRNOT00000083487.3
      Conserved Domains (4) summary
      cd06174
      Location:453 → 623
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:453 → 651
      MFS_1; Major Facilitator Superfamily
      pfam12832
      Location:68 → 143
      MFS_1_like; MFS_1 like family
      pfam16038
      Location:366 → 395
      TMIE; TMIE protein

    4. XM_006244897.5 → XP_006244959.1  major facilitator superfamily domain-containing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006244959.1

      UniProtKB/TrEMBL
      A0A0G2JW92, A6INV8, D3ZCJ3
      Conserved Domains (4) summary
      cd06174
      Location:453 → 623
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:453 → 651
      MFS_1; Major Facilitator Superfamily
      pfam12832
      Location:68 → 143
      MFS_1_like; MFS_1 like family
      pfam16038
      Location:366 → 395
      TMIE; TMIE protein
    Nucleotide Protein Strain
    Heading Accession and Version

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